Phagocytic 'teeth'and myosin-II 'jaw'power target constriction during phagocytosis

D Vorselen, SR Barger, Y Wang, W Cai, JA Theriot… - Elife, 2021 - elifesciences.org
Phagocytosis requires rapid actin reorganization and spatially controlled force generation to
ingest targets ranging from pathogens to apoptotic cells. How actomyosin activity directs …

Inflammation drives stiffness mediated uptake of lipoproteins in primary human macrophages and foam cell proliferation

M Ammanamanchi, M Maurer, HN Hayenga - Annals of biomedical …, 2021 - Springer
Macrophage to foam cell transition and their accumulation in the arterial intima are the key
events that trigger atherosclerosis, a multifactorial inflammatory disease. Previous studies …

Combined Atomic Force Microscopy and Light Sheet Microscopy Characterize the Mechanobiology of Phagocytosis

ME Kern - 2023 - search.proquest.com
Phagocytosis is a fundamental biological function which allows immune cells, such as
macrophages, to internalize and eliminate harmful particles such as pathogens, bacteria …

Elucidating the Biomechanics of MERTK-Mediated Efferocytosis

BH Dickson - 2023 - ir.lib.uwo.ca
Macrophages are key mediators of efferocytosis–the phagocytic engulfment and removal of
apoptotic cells. During engulfment, the coordinated activity of efferocytic receptors induces …