The Photosensitizer Temoporfin (mTHPC) – Chemical, Pre‐clinical and Clinical Developments in the Last Decade

A Wiehe, MO Senge - Photochemistry and Photobiology, 2023 - Wiley Online Library
This review follows the research, development and clinical applications of the
photosensitizer 5, 10, 15, 20‐tetra (m‐hydroxyphenyl) chlorin (m THPC, temoporfin) in …

Ligand-targeted delivery of photosensitizers for cancer treatment

P Gierlich, AI Mata, C Donohoe, RMM Brito, MO Senge… - Molecules, 2020 - mdpi.com
Photodynamic therapy (PDT) is a promising cancer treatment which involves a
photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which …

Multifunctional nanoparticles as photosensitizer delivery carriers for enhanced photodynamic cancer therapy

Y Zhang, B Wang, R Zhao, Q Zhang, X Kong - Materials Science and …, 2020 - Elsevier
Photodynamic therapy (PDT) is an emerging cancer treatment combining light, oxygen, and
a photosensitizer (PS) to produce highly cytotoxic reactive oxygen species that cause cancer …

Promising applications of steroid сonjugates for cancer research and treatment

VА Zolottsev, АS Latysheva, VS Pokrovsky… - European Journal of …, 2021 - Elsevier
The conjugation of biologically active molecules is a powerful tool for drug discovery used to
target a variety of multifunctional diseases including cancer. Conjugated drugs can provide …

Chemical synthesis and medicinal applications of glycoporphyrins

C Moylan, EM Scanlan… - Current Medicinal …, 2015 - ingentaconnect.com
This review presents an in-depth overview of the modification of porphyrins with
bioconjugates and their applications in medicine today. Porphyrin bioconjugates ranging …

One‐Photon and Two‐Photon Photophysical Properties of Tetrafunctionalized 5,10,15,20‐tetrakis(m‐hydroxyphenyl)chlorin (Temoporfin) Derivatives as Potential …

P Gierlich, SG Mucha, E Robbins… - …, 2022 - Wiley Online Library
Photodynamic therapy (PDT) is a cancer treatment, which exploits a photosensitizing drug
and light to produce reactive oxygen species that can cause selective damage to the target …

Nucleophilic Aromatic Substitution (SNAr) and Related Reactions of Porphyrinoids: Mechanistic and Regiochemical Aspects

HC Sample, MO Senge - European Journal of Organic …, 2021 - Wiley Online Library
The nucleophilic substitution of aromatic moieties (SNAr) has been known for over 150
years and found wide use for the functionalization of (hetero) aromatic systems. Currently …

Nanotechnology-based photodynamic therapy: concepts, advances, and perspectives

T Garg, NK Jain, G Rath, A Goyal - Critical Reviews™ in …, 2015 - dl.begellhouse.com
Photodynamic therapy (PDT) is a photoactive process that uses the combination of
photosensitizers (PSs) and specific wavelengths of light for the treatment of solid tumors and …

Silybin-based herbal nanocarriers: an advancement in anticancer therapy

MB Shete, AS Deshpande, P Shende - Materials Technology, 2022 - Taylor & Francis
Silybin is a key bioactive component of silymarin that display health-promoting actions in
many chronic diseases. However, its clinical applicability is curtailed by its inherent issues …

Steroid-photosensitizer conjugates: Syntheses and applications

S Osati, H Ali, B Guerin, JE van Lier - Journal of Porphyrins and …, 2017 - World Scientific
This review focuses on progress in the development of different approaches to the design of
steroid (eg estrogens, androgens, cholesterol) conjugates with coordination assemblies of …