Carotid body chemoreceptors: physiology, pathology, and implications for health and disease

R Iturriaga, J Alcayaga, MW Chapleau… - Physiological …, 2021 - journals.physiology.org
The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

Peripheral chemoreceptors: function and plasticity of the carotid body

P Kumar, NR Prabhakar - Comprehensive Physiology, 2012 - pmc.ncbi.nlm.nih.gov
The discovery of the sensory nature of the carotid body dates back to the beginning of the
20th century. Following these seminal discoveries, research into carotid body mechanisms …

Carotid body chemoreceptors: from natural stimuli to sensory discharges.

C Gonzalez, L Almaraz, A Obeso… - Physiological …, 1994 - journals.physiology.org
Animal respiration is the process by which oxygen (0,) is delivered to the cells to oxidize
nutrients and obtain the energy necessary for all vital functions; carbon dioxide (CO,) is …

Physiology of the carotid body: from molecules to disease

P Ortega-Sáenz, J López-Barneo - Annual review of physiology, 2020 - annualreviews.org
The carotid body (CB) is an arterial chemoreceptor organ located in the carotid bifurcation
and has a well-recognized role in cardiorespiratory regulation. The CB contains …

A novel oxygen‐sensitive potassium current in rat carotid body type I cells.

KJ Buckler - The Journal of Physiology, 1997 - Wiley Online Library
1. Hypoxic stimuli depolarize carotid body type I cells causing voltage‐gated calcium influx.
This study investigates the cause of this membrane depolarization. Isolated type I cells from …

Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells.

J Urena, R Fernandez-Chacon, AR Benot… - Proceedings of the …, 1994 - pnas.org
We have investigated the changes of cytosolic [Ca2+] and the secretory activity in single
glomus cells dispersed from rabbit carotid bodies during exposure to solutions with variable …

Heteromeric TASK‐1/TASK‐3 is the major oxygen‐sensitive background K+ channel in rat carotid body glomus cells

D Kim, EJ Cavanaugh, I Kim… - The Journal of …, 2009 - Wiley Online Library
Carotid body (CB) glomus cells from rat express a TASK‐like background K+ channel that is
believed to play a critical role in the regulation of excitability and hypoxia‐induced increase …

TASK channels in arterial chemoreceptors and their role in oxygen and acid sensing

KJ Buckler - Pflügers Archiv-European Journal of Physiology, 2015 - Springer
Arterial chemoreceptors play a vital role in cardiorespiratory control by providing the brain
with information regarding blood oxygen, carbon dioxide, and pH. The main chemoreceptor …

Carotid body oxygen sensing

J López-Barneo, P Ortega-Sáenz… - European …, 2008 - publications.ersnet.org
The carotid body (CB) is a neural crest-derived organ whose major function is to sense
changes in arterial oxygen tension to elicit hyperventilation in hypoxia. The CB is composed …

Oxygen and acid chemoreception in the carotid body chemoreceptors

C Gonzalez, L Almaraz, A Obeso, R Rigual - Trends in neurosciences, 1992 - cell.com
The carotid bodies are arterial chemoreceptors that are sensitive to blood Poe, Pco2 and
pH. They are the origin of reflexes that are crucial for maintaining Pco~ and pH in the …