Monocytes are innate immune cells of the mononuclear phagocyte system that have
emerged as important regulators of cancer development and progression. Our …

Chemokines are chemotactic cytokines that mediate immune cell chemotaxis and lymphoid
tissue development. Recent advances have indicated that chemokines and their cognate …

The immune response influences the clinical course of colorectal cancer (CRC). Analyzing
the invasive margin of human CRC liver metastases, we identified a mechanism of immune …

Inflammation is now a well-recognized hallmark of cancer progression. Tumor-associated
macrophages (TAMs) are one of the major inflammatory cells that infiltrate murine and …

Toll-like receptors (TLRs) are essential receptors involved in inflammation and innate
immunity. Various types of cancer cells, as well as innate immune cells, express TLRs …

Chemokines, binding their various G protein-coupled receptors, lead the way for leukocytes
in health and inflammation. Yet chemokine receptor expression is not limited to leukocytes …

Monocytes and tumor-associated macrophages are part of the myeloid family, a group of
hematopoietic derived cells. Monocytes are direct precursors of hematopoietic stem cell …

B cell acute lymphoblastic leukemia (B-ALL) blasts hijack the bone marrow (BM)
microenvironment to form chemoprotective leukemic BM “niches,” facilitating …

Genetic lesions predisposing to pediatric B-cell acute lymphoblastic leukemia (B-ALL) arise
in utero, generating a clinically silent pre-leukemic phase. We here reviewed the role of the …

Inflammation in the bone marrow (BM) microenvironment is a constitutive component of
leukemogenesis in acute myeloid leukemia (AML). Current evidence suggests that both …