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Inducible nitric oxide synthase: Regulation, structure, and inhibition
MA Cinelli, HT Do, GP Miley… - Medicinal research …, 2020 - Wiley Online Library
A considerable number of human diseases have an inflammatory component, and a key
mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS) …
mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS) …
Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery
CE Paulsen, KS Carroll - Chemical reviews, 2013 - ACS Publications
Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …
respectively, are produced during normal cell function and in response to various stimuli. An …
Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension
Tobacco smoking is a major risk factor for cardiovascular disease and hypertension. It is
associated with the oxidative stress and induces metabolic reprogramming, altering …
associated with the oxidative stress and induces metabolic reprogramming, altering …
Nitric oxide and redox mechanisms in the immune response
The role of redox molecules, such as NO and ROS, as key mediators of immunity has
recently garnered renewed interest and appreciation. To regulate immune responses, these …
recently garnered renewed interest and appreciation. To regulate immune responses, these …
Nitric oxide synthases: structure, function and inhibition
WK Alderton, CE Cooper, RG Knowles - Biochemical journal, 2001 - portlandpress.com
This review concentrates on advances in nitric oxide synthase (NOS) structure, function and
inhibition made in the last seven years, during which time substantial advances have been …
inhibition made in the last seven years, during which time substantial advances have been …
Role of oxidative modifications in atherosclerosis
R Stocker, JF Keaney Jr - Physiological reviews, 2004 - journals.physiology.org
This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …
Oxidative stress in diabetic nephropathy
N Kashihara, Y Haruna, VK Kondeti… - Current medicinal …, 2010 - ingentaconnect.com
Diabetic nephropathy is a leading cause of end-stage renal failure worldwide. Its
morphologic characteristics include glomerular hypertrophy, basement membrane …
morphologic characteristics include glomerular hypertrophy, basement membrane …
The chemical biology of nitric oxide: implications in cellular signaling
DD Thomas, LA Ridnour, JS Isenberg… - Free Radical Biology …, 2008 - Elsevier
Nitric oxide (NO) has earned the reputation of being a signaling mediator with many diverse
and often opposing biological activities. The diversity in response to this simple diatomic …
and often opposing biological activities. The diversity in response to this simple diatomic …
Polyphenol stilbenes: molecular mechanisms of defence against oxidative stress and aging‐related diseases
M Reinisalo, A Kårlund, A Koskela… - Oxidative medicine …, 2015 - Wiley Online Library
Numerous studies have highlighted the key roles of oxidative stress and inflammation in
aging‐related diseases such as obesity, type 2 diabetes, age‐related macular degeneration …
aging‐related diseases such as obesity, type 2 diabetes, age‐related macular degeneration …
eNOS uncoupling in cardiovascular diseases-the role of oxidative stress and inflammation
Many cardiovascular diseases and drug-induced complications are associated with-or even
based on-an imbalance between the formation of reactive oxygen and nitrogen species …
based on-an imbalance between the formation of reactive oxygen and nitrogen species …