Inducible nitric oxide synthase: Regulation, structure, and inhibition

MA Cinelli, HT Do, GP Miley… - Medicinal research …, 2020 - Wiley Online Library
A considerable number of human diseases have an inflammatory component, and a key
mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS) …

Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery

CE Paulsen, KS Carroll - Chemical reviews, 2013 - ACS Publications
Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …

Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension

S Dikalov, H Itani, B Richmond… - American Journal …, 2019 - journals.physiology.org
Tobacco smoking is a major risk factor for cardiovascular disease and hypertension. It is
associated with the oxidative stress and induces metabolic reprogramming, altering …

Nitric oxide and redox mechanisms in the immune response

DA Wink, HB Hines, RYS Cheng… - Journal of leukocyte …, 2011 - academic.oup.com
The role of redox molecules, such as NO and ROS, as key mediators of immunity has
recently garnered renewed interest and appreciation. To regulate immune responses, these …

Nitric oxide synthases: structure, function and inhibition

WK Alderton, CE Cooper, RG Knowles - Biochemical journal, 2001 - portlandpress.com
This review concentrates on advances in nitric oxide synthase (NOS) structure, function and
inhibition made in the last seven years, during which time substantial advances have been …

Role of oxidative modifications in atherosclerosis

R Stocker, JF Keaney Jr - Physiological reviews, 2004 - journals.physiology.org
This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

Oxidative stress in diabetic nephropathy

N Kashihara, Y Haruna, VK Kondeti… - Current medicinal …, 2010 - ingentaconnect.com
Diabetic nephropathy is a leading cause of end-stage renal failure worldwide. Its
morphologic characteristics include glomerular hypertrophy, basement membrane …

The chemical biology of nitric oxide: implications in cellular signaling

DD Thomas, LA Ridnour, JS Isenberg… - Free Radical Biology …, 2008 - Elsevier
Nitric oxide (NO) has earned the reputation of being a signaling mediator with many diverse
and often opposing biological activities. The diversity in response to this simple diatomic …

Polyphenol stilbenes: molecular mechanisms of defence against oxidative stress and aging‐related diseases

M Reinisalo, A Kårlund, A Koskela… - Oxidative medicine …, 2015 - Wiley Online Library
Numerous studies have highlighted the key roles of oxidative stress and inflammation in
aging‐related diseases such as obesity, type 2 diabetes, age‐related macular degeneration …

eNOS uncoupling in cardiovascular diseases-the role of oxidative stress and inflammation

S Karbach, P Wenzel, A Waisman… - Current …, 2014 - benthamdirect.com
Many cardiovascular diseases and drug-induced complications are associated with-or even
based on-an imbalance between the formation of reactive oxygen and nitrogen species …