Natural products modulating epigenetic mechanisms by affecting histone methylation/demethylation: Targeting cancer cells
D Dorna, A Grabowska… - British Journal of …, 2023 - Wiley Online Library
Many natural products can exert anticancer or chemopreventive activity by interfering with
the cellular epigenetic machinery. Many studies indicate the relevance of affecting DNA …
the cellular epigenetic machinery. Many studies indicate the relevance of affecting DNA …
[HTML][HTML] Naturally occurring xanthones and their biological implications
AO Oriola, P Kar - Molecules, 2024 - pmc.ncbi.nlm.nih.gov
Xanthones are chemical substances in higher plants, marine organisms, and lower
microorganisms. The most prevalent naturally occurring sources of xanthones are those …
microorganisms. The most prevalent naturally occurring sources of xanthones are those …
γ-Mangostin abrogates AINT-induced cholestatic liver injury: Impact on Nrf2/NF-κB/NLRP3/Caspase-1/IL-1β/GSDMD signalling
Abstract γ-Mangostin (γ-MN) is one of the abundant xanthones separated from Garcinia
mangostana (Clusiaceae) pericarps that has been reported to have varied bioactivities such …
mangostana (Clusiaceae) pericarps that has been reported to have varied bioactivities such …
Synthetic and Natural Xanthones as Antibacterial Agents
J Prathiksha, TS Murali, R Nayak - ChemistrySelect, 2024 - Wiley Online Library
Xanthones, a class of polyketide derivatives characterized by a dibenzo‐γ‐pyrone core
structure, are aromatic oxygenated cyclic compounds extensively found in nature. They are …
structure, are aromatic oxygenated cyclic compounds extensively found in nature. They are …
Structure and activity relationship analysis of xanthones from mangosteen: Identifying garcinone E as a potent dual EGFR and VEGFR2 inhibitor
Background Xanthones are among the most fundamental phytochemicals in nature. The anti-
cancer activities of xanthones and their derivatives have been extensively studied. Recently …
cancer activities of xanthones and their derivatives have been extensively studied. Recently …
Gartanin as an Isoprenylated Xanthone from Mangosteen (Garcinia mangostana L.): Insights into Its Synthesis, Extraction, Determination, and Bioactivity
Q Zhang, L Wang, H Li, F Wu, Z Tang, H Li… - Food Reviews …, 2024 - Taylor & Francis
ABSTRACT Gartanin, a 4-prenylated xanthone, is a bioactive secondary metabolite found in
mangosteen. In contrast to mangostins, another class of xanthone derivatives in …
mangosteen. In contrast to mangostins, another class of xanthone derivatives in …
Garcixanthone E and Garcimangophenone C: New Metabolites from Garcinia mangostana and Their Cytotoxic and Alpha Amylase Inhibitory Potential
Garcinia mangostana (Clusiaceae) is a rich pool of metabolites with diversified bioactivities.
A new xanthone, garcixanthone E (1), and a new benzophenone, rhamnoside, as well as …
A new xanthone, garcixanthone E (1), and a new benzophenone, rhamnoside, as well as …
Diversity Oriented Synthesis of Novel Xanthones Reveal Potent Doxorubicin‐Inspired Analogs
JW Meringdal, L Bade, G Bendas, D Menche - ChemMedChem, 2024 - Wiley Online Library
Inspired by potent antiproliferative xanthone natural products and so far limited examples of
derived bioactive agents, a structure activity study of architecturally novel types of xanthones …
derived bioactive agents, a structure activity study of architecturally novel types of xanthones …
Production and Biomedical Applications of Bioactive Compounds
The development of drug resistance to presently available synthetic medicines leads us to
investigate naturally produced small bioactive molecules to treat drug-resistant diseases …
investigate naturally produced small bioactive molecules to treat drug-resistant diseases …
Enantioselective synthesis, characterization and biological evaluation of α-alkylated acids
all living organisms produce only one enantiomer so we found that all natural compounds
are presented in enantiomerically pure form. Asymmetric synthesis is highly spread in …
are presented in enantiomerically pure form. Asymmetric synthesis is highly spread in …