Peptides are recognized as being highly selective, potent and relatively safe as potential
therapeutics. Peptides isolated from the venom of different animals satisfy most of these …

Venomous animals have evolved toxins that interfere with specific components of their
victim's core physiological systems, thereby causing biological dysfunction that aids in prey …

Spiders are diverse, predatory arthropods that have inhabited Earth for around 400 million
years. They are well known for their complex venom systems that are used to overpower …

Ants (Formicidae) represent a taxonomically diverse group of hymenopterans with over
13,000 extant species, the majority of which inject or spray secretions from a venom gland …

Spiders are one of the most successful venomous animals, with more than 48,000 described
species. Most spider venoms are dominated by cysteine-rich peptides with a diverse range …

Highlights•Knottins are small constrained peptides with ultra-high stability.•New binding
epitopes can be introduced into natural knottins using protein engineering.•Knottins have …

Spider venoms are complex chemical arsenals that contain a rich variety of insecticidal
toxins. However, the major toxin class in many spider venoms is disulfide‐rich peptides …

Spiders have been evolving complex and diverse repertoires of peptides in their venoms
with vast pharmacological activities for more than 300 million years. Spiders use their …

Here we show that the most venomous spiders in the world are phylogenetically misplaced.
Australian atracine spiders (family Hexathelidae), including the notorious Sydney funnel …

Antimicrobial peptides (AMPs) are cationic amphiphilic molecules with α-helix or β-sheet
linear motifs and linear or cyclic configurations. For their role in 'defense and offense', they …