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Drug resistance in Plasmodium
A marked decrease in malaria-related deaths worldwide has been attributed to the
administration of effective antimalarials against Plasmodium falciparum, in particular …
administration of effective antimalarials against Plasmodium falciparum, in particular …
Organic cation transporters in health and disease
H Koepsell - Pharmacological reviews, 2020 - Elsevier
The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
New developments in anti-malarial target candidate and product profiles
A decade of discovery and development of new anti-malarial medicines has led to a
renewed focus on malaria elimination and eradication. Changes in the way new anti …
renewed focus on malaria elimination and eradication. Changes in the way new anti …
Natural product and natural product derived drugs in clinical trials
Covering: 2008–2013. Previous review: 2008, 25, 475 There are a significant number of
natural product (NP) drugs in development. We review the 100 NP and NP-derived …
natural product (NP) drugs in development. We review the 100 NP and NP-derived …
A novel multiple-stage antimalarial agent that inhibits protein synthesis
There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and
novel modes of action, to widen the scope of treatment and to overcome emerging drug …
novel modes of action, to widen the scope of treatment and to overcome emerging drug …
Drugs in development for malaria
The last two decades have seen a surge in antimalarial drug development with product
development partnerships taking a leading role. Resistance of Plasmodium falciparum to the …
development partnerships taking a leading role. Resistance of Plasmodium falciparum to the …
Malaria biology and disease pathogenesis: insights for new treatments
Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan,
claims the lives of nearly a million children each year in Africa alone and is a top public …
claims the lives of nearly a million children each year in Africa alone and is a top public …
[HTML][HTML] Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials
Strategies to counteract or prevent emerging drug resistance are crucial for the design of
next-generation antimalarials. In the past, resistant parasites were generally identified …
next-generation antimalarials. In the past, resistant parasites were generally identified …
Antimalarial drug discovery—approaches and progress towards new medicines
Malaria elimination has recently been reinstated as a global health priority but current
therapies seem to be insufficient for the task. Elimination efforts require new drug classes …
therapies seem to be insufficient for the task. Elimination efforts require new drug classes …
The open access malaria box: a drug discovery catalyst for neglected diseases
Historically, one of the key problems in neglected disease drug discovery has been
identifying new and interesting chemotypes. Phenotypic screening of the malaria parasite …
identifying new and interesting chemotypes. Phenotypic screening of the malaria parasite …