Drug-tolerant persister (DTP) cell populations were originally discovered in antibiotic-
resistant bacterial biofilms. Similar populations with comparable features have since been …

Adaptive therapy is a dynamic cancer treatment protocol that updates (or 'adapts') treatment
decisions in anticipation of evolving tumor dynamics. This broad term encompasses many …

Inherent or acquired resistance to sotorasib poses a substantialt challenge for NSCLC
treatment. Here, we demonstrate that acquired resistance to sotorasib in isogenic cells …

Elucidating the design principles of regulatory networks driving cellular decision-making has
fundamental implications in map** and eventually controlling cell-fate decisions. Despite …

Background Adaptive therapy aims to tackle cancer drug resistance by leveraging resource
competition between drug-sensitive and resistant cells. Here, we present a theoretical study …

Intratumor heterogeneity reduces treatment efficacy and complicates our understanding of
tumor progression and there is a pressing need to understand the functions of …

Cancer cells, like all other organisms, are adept at switching their phenotype to adjust to the
changes in their environment. Thus, phenotypic plasticity is a quantitative trait that confers a …

Translational research in medicine, defined as the transfer of knowledge and discovery from
the basic sciences to the clinic, is typically achieved through interactions between members …

Since the emergence of a transmissible cancer, devil facial tumour disease (DFT1), in the
1980s, wild Tasmanian devil populations have been in decline. In 2016, a second …

Recent evidence suggests that nongenetic (epigenetic) mechanisms play an important role
at all stages of cancer evolution. In many cancers, these mechanisms have been observed …