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Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes
The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …
de-regulation of this timing promotes the formation of cancer and leads to defects during …
Multifunctional histone variants in genome function
Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …
organization and function of the genome. The dynamic regulation of chromatin involves the …
Comprehensive single-cell transcriptional profiling of a multicellular organism
To resolve cellular heterogeneity, we developed a combinatorial indexing strategy to profile
the transcriptomes of single cells or nuclei, termed sci-RNA-seq (single-cell combinatorial …
the transcriptomes of single cells or nuclei, termed sci-RNA-seq (single-cell combinatorial …
The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities
The DNA-repair capacity in somatic cells is limited compared with that in germ cells. It has
remained unknown whether not only lesion-type-specific, but overall repair capacities could …
remained unknown whether not only lesion-type-specific, but overall repair capacities could …
Cohesin-dependent and-independent mechanisms mediate chromosomal contacts between promoters and enhancers
MJ Thiecke, G Wutz, M Muhar, W Tang, S Bevan… - Cell reports, 2020 - cell.com
It is currently assumed that 3D chromosomal organization plays a central role in
transcriptional control. However, depletion of cohesin and CTCF affects the steady-state …
transcriptional control. However, depletion of cohesin and CTCF affects the steady-state …
Dual role of the histone variant H2A. Z in transcriptional regulation of stress-response genes
The influence of the histone variant H2A. Z on transcription remains a long-standing
conundrum. Here, by analyzing the actin-related protein6 mutant, which is impaired in H2A …
conundrum. Here, by analyzing the actin-related protein6 mutant, which is impaired in H2A …
Condensin I folds the Caenorhabditis elegans genome
The structural maintenance of chromosome (SMC) complexes—cohesin and condensins—
are crucial for chromosome separation and compaction during cell division. During the …
are crucial for chromosome separation and compaction during cell division. During the …
Histone variant H2A. Z. 2 mediates proliferation and drug sensitivity of malignant melanoma
Histone variants are emerging as key regulatory molecules in cancer. We report a unique
role for the H2A. Z isoform H2A. Z. 2 as a driver of malignant melanoma. H2A. Z. 2 is highly …
role for the H2A. Z isoform H2A. Z. 2 as a driver of malignant melanoma. H2A. Z. 2 is highly …
Histone methyltransferase activity affects metabolism in human cells independently of transcriptional regulation
The N-terminal tails of eukaryotic histones are frequently posttranslationally modified. The
role of these modifications in transcriptional regulation is well-documented. However, the …
role of these modifications in transcriptional regulation is well-documented. However, the …
[HTML][HTML] Histone variants and chromatin structure, update of advances
Histone proteins are highly conserved among all eukaryotes. They have two important
functions in the cell: to package the genomic DNA and to regulate gene accessibility …
functions in the cell: to package the genomic DNA and to regulate gene accessibility …