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Principles and applications of nucleic acid strand displacement reactions
Dynamic DNA nanotechnology, a subfield of DNA nanotechnology, is concerned with the
study and application of nucleic acid strand-displacement reactions. Strand-displacement …
study and application of nucleic acid strand-displacement reactions. Strand-displacement …
Nucleic acid aptamers for molecular diagnostics and therapeutics: advances and perspectives
The advent of SELEX (systematic evolution of ligands by exponential enrichment)
technology has shown the ability to evolve artificial ligands with affinity and specificity able to …
technology has shown the ability to evolve artificial ligands with affinity and specificity able to …
A spatially localized DNA linear classifier for cancer diagnosis
Molecular computing is an emerging paradigm that plays an essential role in data storage,
bio-computation, and clinical diagnosis with the future trends of more efficient computing …
bio-computation, and clinical diagnosis with the future trends of more efficient computing …
Ratiometric optical nanoprobes enable accurate molecular detection and imaging
Exploring and understanding biological and pathological changes are of great significance
for early diagnosis and therapy of diseases. Optical sensing and imaging approaches have …
for early diagnosis and therapy of diseases. Optical sensing and imaging approaches have …
Aptamer-based targeted therapy
Precision medicine holds great promise to harness genetic and epigenetic cues for targeted
treatment of a variety of diseases, ranging from many types of cancers, neurodegenerative …
treatment of a variety of diseases, ranging from many types of cancers, neurodegenerative …
Self-adaptive single-atom catalyst boosting selective ferroptosis in tumor cells
Ferroptosis, resulting from the catastrophic accumulation of lipid reactive oxygen species
(ROS) and the inactivation of glutathione (GSH)-dependent peroxidase 4 (GPX4), has …
(ROS) and the inactivation of glutathione (GSH)-dependent peroxidase 4 (GPX4), has …
Self-assembling nucleic acid nanostructures functionalized with aptamers
Researchers have worked for many decades to master the rules of biomolecular design that
would allow artificial biopolymer complexes to self-assemble and function similarly to the …
would allow artificial biopolymer complexes to self-assemble and function similarly to the …
Cancer diagnosis with DNA molecular computation
Early and precise cancer diagnosis substantially improves patient survival. Recent work has
revealed that the levels of multiple microRNAs in serum are informative as biomarkers for …
revealed that the levels of multiple microRNAs in serum are informative as biomarkers for …
Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy
The combination of nanostructures with biomolecules leading to the generation of functional
nanosystems holds great promise for biotechnological and biomedical applications. As a …
nanosystems holds great promise for biotechnological and biomedical applications. As a …
Construction of a multiple-aptamer-based DNA logic device on live cell membranes via associative toehold activation for accurate cancer cell identification
The ability to accurately identify and isolate cells is the cornerstone of precise disease
diagnosis and therapies. A single-step cell identification method based on logic analysis of …
diagnosis and therapies. A single-step cell identification method based on logic analysis of …