The role of glutathione peroxidase-1 in health and disease
DE Handy, J Loscalzo - Free Radical Biology and Medicine, 2022 - Elsevier
Abstract Glutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is
found in the cytoplasm and mitochondria of mammalian cells. Like most selenoenzymes, it …
found in the cytoplasm and mitochondria of mammalian cells. Like most selenoenzymes, it …
The homeostatic role of hydrogen peroxide, superoxide anion and nitric oxide in the vasculature
Reactive oxygen and nitrogen species are produced in a wide range of physiological
reactions that, at low concentrations, play essential roles in living organisms. There is a …
reactions that, at low concentrations, play essential roles in living organisms. There is a …
Selenium, a micronutrient that modulates cardiovascular health via redox enzymology
Selenium (Se) is a trace nutrient that promotes human health through its incorporation into
selenoproteins in the form of the redox-active amino acid selenocysteine (Sec). There are 25 …
selenoproteins in the form of the redox-active amino acid selenocysteine (Sec). There are 25 …
Reactive oxygen species generation and atherosclerosis
e42 Arterioscler Thromb Vasc Biol May 2017 cell adhesion molecule 1), and ICAM1
(intercellular adhesion molecule 1). On the contrary, Apoe−/− Nox4EC aortas contained …
(intercellular adhesion molecule 1). On the contrary, Apoe−/− Nox4EC aortas contained …
Intracoronary optical coherence tomography 2018: current status and future directions
The advent of intravascular imaging has been a significant advancement in visualization of
coronary arteries, particularly with optical coherence tomography (OCT) that allows for high …
coronary arteries, particularly with optical coherence tomography (OCT) that allows for high …
Reactive oxygen species (ROS), intimal thickening, and subclinical atherosclerotic disease
D Burtenshaw, M Kitching, EM Redmond… - Frontiers in …, 2019 - frontiersin.org
Arteriosclerosis causes significant morbidity and mortality worldwide. Central to this process
is the development of subclinical non-atherosclerotic intimal lesions before the appearance …
is the development of subclinical non-atherosclerotic intimal lesions before the appearance …
The mechanisms of restenosis and relevance to next generation stent design
Stents are lifesaving mechanical devices that re-establish essential blood flow to the
coronary circulation after significant vessel occlusion due to coronary vessel disease or …
coronary circulation after significant vessel occlusion due to coronary vessel disease or …
Responses to reductive stress in the cardiovascular system
DE Handy, J Loscalzo - Free Radical Biology and Medicine, 2017 - Elsevier
There is a growing appreciation that reductive stress represents a disturbance in the redox
state that is harmful to biological systems. On a cellular level, the presence of increased …
state that is harmful to biological systems. On a cellular level, the presence of increased …
Deep learning-derived cardiovascular age shares a genetic basis with other cardiac phenotypes
Artificial intelligence (AI)-based approaches can now use electrocardiograms (ECGs) to
provide expert-level performance in detecting heart abnormalities and diagnosing disease …
provide expert-level performance in detecting heart abnormalities and diagnosing disease …
Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis
RJ Roth Flach, A Skoura, A Matevossian… - Nature …, 2015 - nature.com
Signalling pathways that control endothelial cell (EC) permeability, leukocyte adhesion and
inflammation are pivotal for atherosclerosis initiation and progression. Here we demonstrate …
inflammation are pivotal for atherosclerosis initiation and progression. Here we demonstrate …