Pioneer factors as master regulators of the epigenome and cell fate

A Balsalobre, J Drouin - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Pioneer factors are transcription factors with the unique ability to initiate opening of closed
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …

Aging in a dish: iPSC-derived and directly induced neurons for studying brain aging and age-related neurodegenerative diseases

J Mertens, D Reid, S Lau, Y Kim… - Annual review of …, 2018 - annualreviews.org
Age-associated neurological diseases represent a profound challenge in biomedical
research as we are still struggling to understand the interface between the aging process …

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons

Y Shi, S Lin, KA Staats, Y Li, WH Chang, ST Hung… - Nature medicine, 2018 - nature.com
An intronic GGGGCC repeat expansion in C9ORF72 is the most common cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic …

Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin-producing neurons

J Jo, Y **ao, AX Sun, E Cukuroglu, HD Tran, J Göke… - Cell stem cell, 2016 - cell.com
Recent advances in 3D culture systems have led to the generation of brain organoids that
resemble different human brain regions; however, a 3D organoid model of the midbrain …

[HTML][HTML] Super-enhancers in the control of cell identity and disease

D Hnisz, BJ Abraham, TI Lee, A Lau, V Saint-André… - Cell, 2013 - cell.com
Super-enhancers are large clusters of transcriptional enhancers that drive expression of
genes that define cell identity. Improved understanding of the roles that super-enhancers …

[HTML][HTML] Rapid single-step induction of functional neurons from human pluripotent stem cells

Y Zhang, CH Pak, Y Han, H Ahlenius, Z Zhang… - Neuron, 2013 - cell.com
Available methods for differentiating human embryonic stem cells (ESCs) and induced
pluripotent cells (iPSCs) into neurons are often cumbersome, slow, and variable …

In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model

Z Guo, L Zhang, Z Wu, Y Chen, F Wang, G Chen - Cell stem cell, 2014 - cell.com
Loss of neurons after brain injury and in neurodegenerative disease is often accompanied
by reactive gliosis and scarring, which are difficult to reverse with existing treatment …

Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq

B Treutlein, QY Lee, JG Camp, M Mall, W Koh… - Nature, 2016 - nature.com
Direct lineage reprogramming represents a remarkable conversion of cellular and
transcriptome states,,. However, the intermediate stages through which individual cells …

Generation of pure GABAergic neurons by transcription factor programming

N Yang, S Chanda, S Marro, YH Ng, JA Janas… - Nature …, 2017 - nature.com
Approaches to differentiating pluripotent stem cells (PSCs) into neurons currently face two
major challenges—(i) generated cells are immature, with limited functional properties; and …

Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style

AJ Merrell, BZ Stanger - Nature reviews Molecular cell biology, 2016 - nature.com
Biologists have long been intrigued by the possibility that cells can change their identity, a
phenomenon known as cellular plasticity. The discovery that terminally differentiated cells …