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Pioneer factors as master regulators of the epigenome and cell fate
A Balsalobre, J Drouin - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Pioneer factors are transcription factors with the unique ability to initiate opening of closed
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …
Aging in a dish: iPSC-derived and directly induced neurons for studying brain aging and age-related neurodegenerative diseases
Age-associated neurological diseases represent a profound challenge in biomedical
research as we are still struggling to understand the interface between the aging process …
research as we are still struggling to understand the interface between the aging process …
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
An intronic GGGGCC repeat expansion in C9ORF72 is the most common cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic …
Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin-producing neurons
Recent advances in 3D culture systems have led to the generation of brain organoids that
resemble different human brain regions; however, a 3D organoid model of the midbrain …
resemble different human brain regions; however, a 3D organoid model of the midbrain …
[HTML][HTML] Super-enhancers in the control of cell identity and disease
Super-enhancers are large clusters of transcriptional enhancers that drive expression of
genes that define cell identity. Improved understanding of the roles that super-enhancers …
genes that define cell identity. Improved understanding of the roles that super-enhancers …
[HTML][HTML] Rapid single-step induction of functional neurons from human pluripotent stem cells
Available methods for differentiating human embryonic stem cells (ESCs) and induced
pluripotent cells (iPSCs) into neurons are often cumbersome, slow, and variable …
pluripotent cells (iPSCs) into neurons are often cumbersome, slow, and variable …
In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model
Loss of neurons after brain injury and in neurodegenerative disease is often accompanied
by reactive gliosis and scarring, which are difficult to reverse with existing treatment …
by reactive gliosis and scarring, which are difficult to reverse with existing treatment …
Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq
Direct lineage reprogramming represents a remarkable conversion of cellular and
transcriptome states,,. However, the intermediate stages through which individual cells …
transcriptome states,,. However, the intermediate stages through which individual cells …
Generation of pure GABAergic neurons by transcription factor programming
Approaches to differentiating pluripotent stem cells (PSCs) into neurons currently face two
major challenges—(i) generated cells are immature, with limited functional properties; and …
major challenges—(i) generated cells are immature, with limited functional properties; and …
Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style
AJ Merrell, BZ Stanger - Nature reviews Molecular cell biology, 2016 - nature.com
Biologists have long been intrigued by the possibility that cells can change their identity, a
phenomenon known as cellular plasticity. The discovery that terminally differentiated cells …
phenomenon known as cellular plasticity. The discovery that terminally differentiated cells …