The role of platelets in immune-mediated inflammatory diseases
Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …
Sickle cell disease: a review
PL Kavanagh, TA Fasipe, T Wun - Jama, 2022 - jamanetwork.com
Importance Sickle cell disease (SCD) is an inherited disorder of hemoglobin, characterized
by formation of long chains of hemoglobin when deoxygenated within capillary beds …
by formation of long chains of hemoglobin when deoxygenated within capillary beds …
Guidelines on the use of therapeutic apheresis in clinical practice–evidence‐based approach from the Writing Committee of the American Society for Apheresis: the …
L Connelly‐Smith, CR Alquist, NA Aqui… - Journal of clinical …, 2023 - Wiley Online Library
Abstract The American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA)
Special Issue Writing Committee is charged with reviewing, updating, and categorizing …
Special Issue Writing Committee is charged with reviewing, updating, and categorizing …
CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease
Background Sickle cell disease is caused by a defect in the β-globin subunit of adult
hemoglobin. Sickle hemoglobin polymerizes under hypoxic conditions, producing deformed …
hemoglobin. Sickle hemoglobin polymerizes under hypoxic conditions, producing deformed …
CRISPR-Cas9 gene editing for sickle cell disease and β-thalassemia
Transfusion-dependent β-thalassemia (TDT) and sickle cell disease (SCD) are severe
monogenic diseases with severe and potentially life-threatening manifestations. BCL11A is …
monogenic diseases with severe and potentially life-threatening manifestations. BCL11A is …
The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans
Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …
Inflammation, infection and venous thromboembolism
ME Colling, BE Tourdot, Y Kanthi - Circulation research, 2021 - ahajournals.org
The association between inflammation, infection, and venous thrombosis has long been
recognized; yet, only in the last decades have we begun to understand the mechanisms …
recognized; yet, only in the last decades have we begun to understand the mechanisms …
American Society of Hematology 2020 guidelines for sickle cell disease: management of acute and chronic pain
AM Brandow, CP Carroll, S Creary, R Edwards-Elliott… - Blood advances, 2020 - Elsevier
Background: The management of acute and chronic pain for individuals living with sickle cell
disease (SCD) is a clinical challenge. This reflects the paucity of clinical SCD pain research …
disease (SCD) is a clinical challenge. This reflects the paucity of clinical SCD pain research …
Sickle cell disease
Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB,
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …
A Phase 3 Trial of l-Glutamine in Sickle Cell Disease
Background Oxidative stress contributes to the complex pathophysiology of sickle cell
disease. Oral therapy with pharmaceutical-grade l-glutamine (USAN, glutamine) has been …
disease. Oral therapy with pharmaceutical-grade l-glutamine (USAN, glutamine) has been …