Somatic mutations in cancer cells can generate tumour-specific neoepitopes, which are
recognized by autologous T cells in the host. As neoepitopes are not subject to central …

Malignant transformation of cells depends on accumulation of DNA damage. Over the past
years we have learned that the T cell–based immune system frequently responds to the …

Cytotoxic T cells are of central importance in the immune system's response to disease.
They recognize defective cells by binding to peptides presented on the cell surface by MHC …

Mobilizing antitumour immunity through vaccination potentially constitutes a powerful
anticancer strategy but has not yet provided robust clinical benefits in large patient …

Accurate prediction of antigen presentation by human leukocyte antigen (HLA) class II
molecules would be valuable for vaccine development and cancer immunotherapies …

Identification of human leukocyte antigen (HLA)-bound peptides by liquid chromatography-
tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules …

Motivation: Many biological processes are guided by receptor interactions with linear
ligands of variable length. One such receptor is the MHC class I molecule. The length …

Immunotherapies are yielding effective treatments for several previously untreatable
cancers. Still, the identification of suitable antigens specific to the tumour that can be targets …

Identification of neoantigens is a critical step in predicting response to checkpoint blockade
therapy and design of personalized cancer vaccines. This is a cross-disciplinary challenge …

Recent breakthroughs in cancer immunotherapy and decreasing costs of high-throughput
technologies have sparked intensive research into tumour–immune cell interactions using …