Dry eye disease (DED) is a frequently observed eye complaint, which has recently attracted
considerable research interest. Conventional therapy for DED involves the use of artificial …

Limbal stem cells (LSCs) maintain the normal homeostasis and wound healing of corneal
epithelium. Limbal stem cell deficiency (LSCD) is a pathologic condition that results from the …

Ex vivo cultured limbal epithelial stem cells have been used successfully to treat corneal
limbal stem cell deficiency. We identified 17 reports of the application of this novel cell …

purpose. To study the in vitro and in vivo interaction of chitosan nanoparticles (CSNPs), a
new particulate drug carrier, with epithelial cells on the ocular surface. methods. CSNPs …

Mucins are key actors in tear film quality and tear film stability. Alteration of membrane-
bound mucin expression on corneal and conjunctival epithelial cells and/or gel-forming …

This study evaluated in vitro and in vivo a colloidal nanosystem with the potential to deliver
drugs to the ocular surface. This nanosystem, liposome–chitosan nanoparticle complexes …

Dry eye syndrome (DES) or keratoconjunctivitis sicca (KCS) is a common disorder of the tear
film caused by decreased tear production or increased evaporation and manifests with a …

Corneal wound healing studies have a long history and rich literature that describes the data
obtained over the past 70 years using many different species of animals and methods of …

Dry eye disease (DED) is a multifactorial disorder of the tear film and ocular surface that
results in eye discomfort, visual disturbance, and often ocular surface damage. Although …

Purpose: The aim of this study was to compare, in vivo on a rat model, two different
preservatives—benzalkonium chloride (BAC) and polyquaternium-1 (PQ-1)—using new …