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Network abnormalities and interneuron dysfunction in Alzheimer disease
The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …
Neuroprosthetics: from sensorimotor to cognitive disorders
A Gupta, N Vardalakis, FB Wagner - Communications biology, 2023 - nature.com
Neuroprosthetics is a multidisciplinary field at the interface between neurosciences and
biomedical engineering, which aims at replacing or modulating parts of the nervous system …
biomedical engineering, which aims at replacing or modulating parts of the nervous system …
Dendritic tau in Alzheimer's disease
The microtubule-associated protein tau and amyloid-β (Aβ) are key players in Alzheimer's
disease (AD). Aβ and tau are linked in a molecular pathway at the post-synapse with tau …
disease (AD). Aβ and tau are linked in a molecular pathway at the post-synapse with tau …
[HTML][HTML] Involvement of p38 MAPK in synaptic function and dysfunction
C Falcicchia, F Tozzi, O Arancio, DM Watterson… - International journal of …, 2020 - mdpi.com
Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the
regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) …
regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) …
Functions of p38 MAP kinases in the central nervous system
PR Asih, E Prikas, K Stefanoska, ARP Tan… - Frontiers in molecular …, 2020 - frontiersin.org
Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …
multitude of mammalian cell types. This review covers recent advances on specific functions …
Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice
A Ittner, SW Chua, J Bertz, A Volkerling… - Science, 2016 - science.org
Amyloid-β (Aβ) toxicity in Alzheimer's disease (AD) is considered to be mediated by
phosphorylated tau protein. In contrast, we found that, at least in early disease, site-specific …
phosphorylated tau protein. In contrast, we found that, at least in early disease, site-specific …
Tau exacerbates excitotoxic brain damage in an animal model of stroke
M Bi, A Gladbach, J Van Eersel, A Ittner… - Nature …, 2017 - nature.com
Neuronal excitotoxicity induced by aberrant excitation of glutamatergic receptors contributes
to brain damage in stroke. Here we show that tau-deficient (tau−/−) mice are profoundly …
to brain damage in stroke. Here we show that tau-deficient (tau−/−) mice are profoundly …
Leveraging preclinical models for the development of Alzheimer disease therapeutics
K Scearce-Levie, PE Sanchez… - Nature reviews drug …, 2020 - nature.com
A large number of mouse models have been engineered, characterized and used to
advance biomedical research in Alzheimer disease (AD). Early models simply damaged the …
advance biomedical research in Alzheimer disease (AD). Early models simply damaged the …
Neuronal network excitability in Alzheimer's disease: the puzzle of similar versus divergent roles of amyloid β and tau
Alzheimer's disease (AD) is the most frequent neurodegenerative disorder that commonly
causes dementia in the elderly. Recent evidence indicates that network abnormalities …
causes dementia in the elderly. Recent evidence indicates that network abnormalities …
Chemical knockdown of phosphorylated p38 mitogen-activated protein kinase (MAPK) as a novel approach for the treatment of Alzheimer′ s disease
Targeted protein degradation (TPD) provides unique advantages over gene knockdown in
that it can induce selective degradation of disease-associated proteins attributed to …
that it can induce selective degradation of disease-associated proteins attributed to …