Multitargeted therapy of cancer by silymarin

K Ramasamy, R Agarwal - Cancer letters, 2008‏ - Elsevier
Silymarin, a flavonolignan from milk thistle (Silybum marianum) plant, is used for the
protection against various liver conditions in both clinical settings and experimental models …

Anticancer potential of silymarin: from bench to bed side

R Agarwal, C Agarwal, H Ichikawa, RP Singh… - Anticancer …, 2006‏ - ar.iiarjournals.org
Silymarin consists of a family of flavonoids (silybin, isosilybin, silychristin, silydianin and
taxifoline) commonly found in the dried fruit of the milk thistle plant Silybum marianum …

[PDF][PDF] Silymarin modulates cisplatin-induced oxidative stress and hepatotoxicity in rats

HH Mansour, HF Hafez, NM Fahmy - BMB Reports, 2006‏ - academia.edu
Cisplatin [cis-diamminechloroplatinum (II)](CDDP) is a potent antineoplastic agent used for
the treatment of a wide range of cancers (Saad et al., 2004; Wang et al., 2004) …

Anti-Parkinson potential of silymarin: Mechanistic insight and therapeutic standing

H Ullah, H Khan - Frontiers in pharmacology, 2018‏ - frontiersin.org
Parkinson's disease (PD) involves aggregation of α-synuclein and progressive loss of
dopaminergic neurons. Pathogenesis of PD may also be related to one's genetic …

Phytochemicals for the management of melanoma

H Chandra Pal, K Marchiony Hunt… - Mini reviews in …, 2016‏ - benthamdirect.com
Melanoma claims approximately 80% of skin cancer-related deaths. Its life-threatening
nature is primarily due to a propensity to metastasize. The prognosis for melanoma patients …

Unlocking the possibilities of therapeutic potential of silymarin and silibinin against neurodegenerative diseases-a mechanistic overview

S Ashique, S Mohanto, N Kumar, S Nag… - European Journal of …, 2024‏ - Elsevier
Silymarin, a bioflavonoid derived from the Silybum marianum plant, was discovered in 1960.
It contains C 25 and has been extensively used as a therapeutic agent against liver-related …

Effects of Silybum marianum on serum hepatitis C virus RNA, alanine aminotransferase levels and well‐being in patients with chronic hepatitis C

A Gordon, DA Hobbs, DS Bowden… - Journal of …, 2006‏ - Wiley Online Library
Abstract Background/Aims: Silybum marianum is a herbal preparation commonly used by
subjects with chronic hepatitis C (CHC). The aims of this pilot study were to assess the …

Synthesis and antihepatotoxic activity of dihydropyrimidinone derivatives linked with 1, 4-benzodioxane

MA Bhat, MA Al-Omar, AA Khan… - Drug Design …, 2019‏ - Taylor & Francis
Purpose: To evaluate the antihepatotoxic activity of dihydropyrimidinone derivative linked
with 1, 4-benzodioxane. Methods: A series of novel dihydropyrimidinone derivatives linked …

Lipophilic flavones of Primula veris L. from field cultivation and in vitro cultures

J Budzianowski, M Morozowska, M Wesołowska - Phytochemistry, 2005‏ - Elsevier
Ten lipophilic flavones were isolated from the leaves of Primula veris from field cultivation–
the newly described 3′-hydroxy-4′, 5′-dimethoxyflavone and 3′-methoxy-4′, 5 …

Synthesis and biology of 1, 4-benzodioxane lignan natural products

LI Pilkington, D Barker - Natural Product Reports, 2015‏ - pubs.rsc.org
Covering: up to 2015 Lignan-derived 1, 4-benzodioxane natural products have been shown
to exhibit a diverse array of biological activities, which has lent them to be the focus of a …