Structural biology and molecular pharmacology of voltage-gated ion channels
Voltage-gated ion channels (VGICs), including those for Na+, Ca2+ and K+, selectively
permeate ions across the cell membrane in response to changes in membrane potential …
permeate ions across the cell membrane in response to changes in membrane potential …
Medicinal plants for epileptic seizures: Phytoconstituents, pharmacology and mechanisms revisited
X He, X Chen, Y Yang, Y **e, Y Liu - Journal of ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Epilepsy is a neurological disorder that presents with
recurring and spontaneous seizures. It is prevalent worldwide, affecting up to 65 million …
recurring and spontaneous seizures. It is prevalent worldwide, affecting up to 65 million …
Dual-pocket inhibition of Nav channels by the antiepileptic drug lamotrigine
Voltage-gated sodium (Nav) channels govern membrane excitability, thus setting the
foundation for various physiological and neuronal processes. Nav channels serve as the …
foundation for various physiological and neuronal processes. Nav channels serve as the …
Ligand activation mechanisms of human KCNQ2 channel
D Ma, Y Zheng, X Li, X Zhou, Z Yang, Y Zhang… - Nature …, 2023 - nature.com
The human voltage-gated potassium channel KCNQ2/KCNQ3 carries the neuronal M-
current, which helps to stabilize the membrane potential. KCNQ2 can be activated by …
current, which helps to stabilize the membrane potential. KCNQ2 can be activated by …
Structural basis for human Cav1. 2 inhibition by multiple drugs and the neurotoxin calciseptine
Ca v 1.2 channels play crucial roles in various neuronal and physiological processes. Here,
we present cryo-EM structures of human Ca v 1.2, both in its apo form and in complex with …
we present cryo-EM structures of human Ca v 1.2, both in its apo form and in complex with …
A versatile residue numbering scheme for Nav and Cav channels
Voltage-gated sodium (Na v) and calcium (Ca v) channels are responsible for the initiation
of electrical signals. They have long been targeted for the treatment of various diseases. The …
of electrical signals. They have long been targeted for the treatment of various diseases. The …
In-situ reconstructed Cu/NiO nanosheets synergistically boosting nitrate electroreduction to ammonia
Electrochemical reduction of nitrate (NO 3−) serves as an eco-friendly friendly alternative to
the conventional Haber-Bosch ammonia (NH 3) synthesis process. The Cu electrocatalyst is …
the conventional Haber-Bosch ammonia (NH 3) synthesis process. The Cu electrocatalyst is …
Bioinspired Printable Tough Adhesives with In Situ Benignly Triggered Mechanical Enhancements
Adhesives can intimately connect humans to machines, seamlessly bond diverse tissues in
the human body, and manage various diseases. However, the precise spatial control of wet …
the human body, and manage various diseases. However, the precise spatial control of wet …
Neuropathic Pain, Mood, and Stress-Related Disorders: A Literature Review of Comorbidity and Co-Pathogenesis
Neuropathic pain can be caused by multiple factors, and its prevalence can reach 10% of
the global population. It is becoming increasingly evident that limited or short-lasting …
the global population. It is becoming increasingly evident that limited or short-lasting …
Cannabis constituents for chronic neuropathic pain; reconciling the clinical and animal evidence
E Sokolaj, N Assareh, K Anderson… - Journal of …, 2024 - Wiley Online Library
Chronic neuropathic pain is a debilitating pain syndrome caused by damage to the nervous
system that is poorly served by current medications. Given these problems, clinical studies …
system that is poorly served by current medications. Given these problems, clinical studies …