Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …

Glioma is one of the most common and lethal brain tumors. Surgical resection followed by
radiotherapy plus chemotherapy is the current standard of care for patients with glioma. The …

Abundant macrophage infiltration and altered tumor metabolism are two key hallmarks of
glioblastoma. By screening a cluster of metabolic small-molecule compounds, we show that …

Characterizing metabolism in cancer is crucial for understanding tumor biology and for
develo** potential therapies. Although most metabolic investigations analyze averaged …

Glioblastomas are the most malignant brain tumors, whose progress was promoted by
aberrate aerobic glycolysis. The immune environment was highly engaged in glioblastoma …

Aerobic glycolysis is the primary energy supply mode for glioblastoma (GBM) cells to
maintain growth and proliferation. However, due to the metabolic reprogramming of tumor …

Malignant glioma represents a fatal disease with a poor prognosis and development of
resistance mechanisms against conventional therapeutic approaches. The distinct tumor …

Numerous cancer types have shown to present hypermethylation of CpG islands, also
known as a CpG island methylator phenotype (CIMP), often associated with survival …

Telomere maintenance is a universal hallmark of cancer. Most tumors including low-grade
oligodendrogliomas use telomerase reverse transcriptase (TERT) expression for telomere …

Immunotherapy has become a successful therapeutic strategy in certain solid tumors and
hematological malignancies. However, this efficacy of immunotherapy is impeded by limited …