Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

Dynamic nuclear polarization for sensitivity enhancement in biomolecular solid-state NMR

T Biedenbänder, V Aladin, S Saeidpour… - Chemical …, 2022 - ACS Publications
Solid-state NMR with magic-angle spinning (MAS) is an important method in structural
biology. While NMR can provide invaluable information about local geometry on an atomic …

Parahydrogen‐based hyperpolarization for biomedicine

JB Hövener, AN Pravdivtsev, B Kidd… - Angewandte Chemie …, 2018 - Wiley Online Library
Magnetic resonance (MR) is one of the most versatile and useful physical effects used for
human imaging, chemical analysis, and the elucidation of molecular structures. However, its …

Hyperpolarized NMR Spectroscopy: d‐DNP, PHIP, and SABRE Techniques

KV Kovtunov, EV Pokochueva… - Chemistry–An Asian …, 2018 - Wiley Online Library
The intensity of NMR signals can be enhanced by several orders of magnitude by using
various techniques for the hyperpolarization of different molecules. Such approaches can …

Soluble gp130 is the natural inhibitor of soluble interleukin‐6 receptor transsignaling responses

T Jostock, J Müllberg, S Özbek, R Atreya… - European journal of …, 2001 - Wiley Online Library
Signal transduction in response to interleukin‐6 (IL‐6) requires binding of the cytokine to its
receptor (IL‐6R) and subsequent homodimerization of the signal transducer gp130. The …

Over 20% carbon-13 polarization of perdeuterated pyruvate using reversible exchange with parahydrogen and spin-lock induced crossing at 50 μT

AB Schmidt, J Eills, L Dagys, M Gierse… - The Journal of …, 2023 - ACS Publications
Carbon-13 hyperpolarized pyruvate is about to become the next-generation contrast agent
for molecular magnetic resonance imaging of cancer and other diseases. Here, efficient and …

Signal amplification by reversible exchange (SABRE): From discovery to diagnosis

PJ Rayner, SB Duckett - Angewandte Chemie International …, 2018 - Wiley Online Library
Signal amplification by reversible exchange (SABRE) turns typically weak magnetic
resonance responses into strong signals making previously impractical measurements …

LIGHT-SABRE enables efficient in-magnet catalytic hyperpolarization

T Theis, M Truong, AM Coffey, EY Chekmenev… - Journal of Magnetic …, 2014 - Elsevier
Nuclear spin hyperpolarization overcomes the sensitivity limitations of traditional NMR and
MRI, but the most general method demonstrated to date (dynamic nuclear polarization) has …

Instrumentation for hydrogenative parahydrogen-based hyperpolarization techniques

AB Schmidt, CR Bowers, K Buckenmaier… - Analytical …, 2022 - ACS Publications
The unique properties of the entangled, antisymmetric nuclear spin state of dihydrogen,
parahydrogen (pH2), has intrigued physicists, chemists, and other scientists for almost a …

MATRESHCA: microtesla apparatus for transfer of resonance enhancement of spin hyperpolarization via chemical exchange and addition

S Nantogma, MRH Chowdhury, MSH Kabir… - Analytical …, 2024 - ACS Publications
We present an integrated, open-source device for parahydrogen-based hyperpolarization
processes in the microtesla field regime with a cost of components of less than $7000. The …