Pathogenicity and virulence of malaria: Sticky problems and tricky solutions

IS Walker, SJ Rogerson - Virulence, 2023 - Taylor & Francis
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …

Cerebral malaria—using the retina to study the brain

NAV Beare - Eye, 2023 - nature.com
Cerebral malaria (CM) remains a common cause of death of children in Africa with annual
mortality of 400 000. Malarial retinopathy is a unique set of fundus signs which has …

Cerebrospinal fluid biomarkers provide evidence for kidney-brain axis involvement in cerebral malaria pathogenesis

AL Conroy, D Datta, RO Opoka, A Batte… - Frontiers in Human …, 2023 - frontiersin.org
Introduction Cerebral malaria is one of the most severe manifestations of malaria and is a
leading cause of acquired neurodisability in African children. Recent studies suggest acute …

Elevated plasma interleukin-8 as a risk factor for mortality in children presenting with cerebral malaria

J Royo, B Vianou, M Accrombessi, E Kinkpé… - Infectious Diseases of …, 2023 - mednexus.org
Background Cerebral malaria (CM) is a neuropathology which remains one of the deadliest
forms of malaria among African children. The kinetics of the pathophysiological mechanisms …

Retinal imaging technologies in cerebral malaria: a systematic review

KJ Wilson, A Dhalla, Y Meng, Z Tu, Y Zheng, P Mhango… - Malaria journal, 2023 - Springer
Background Cerebral malaria (CM) continues to present a major health challenge,
particularly in sub-Saharan Africa. CM is associated with a characteristic malarial …

Unveiling new perspectives about the onset of neurological and cognitive deficits in cerebral malaria: exploring cellular and neurochemical mechanisms

RMS de Lima, LKR Leão, LC Martins… - Frontiers in Cellular …, 2025 - frontiersin.org
Cerebral malaria is the most severe and lethal complication caused by Plasmodium
falciparum infection, leading to critical neurological impairments and long-term cognitive …

Exploring the hidden mental health consequences of malaria beyond the fever

P Nandish, S BM, SN N, G Shankar… - Frontiers in Human …, 2024 - frontiersin.org
Malaria morbidity has various presentations and the focus now shifts to uncommon signs
and symptoms of malaria infection such as cognitive impairment to address the morbidity …

From Bench to Bedside: Unraveling Cerebral Malaria and Malarial Retinopathy by Combining Clinical and Pre-Clinical Perspectives

S McDonnell, IJ MacCormick, K Harkin… - Current Eye …, 2025 - Taylor & Francis
Infection with Plasmodium falciparum carries a significant risk of cerebral malaria (CM).
Children are particularly susceptible to human CM (HCM) which manifests as an acute …

[HTML][HTML] Unveiling new perspectives about the onset of neurological and cognitive deficits in cerebral malaria: exploring cellular and neurochemical mechanisms

RMS de Lima, LKR Leão, LC Martins… - Frontiers in Cellular …, 2025 - pmc.ncbi.nlm.nih.gov
Cerebral malaria is the most severe and lethal complication caused by Plasmodium
falciparum infection, leading to critical neurological impairments and long-term cognitive …

Clinical aspects of malarial retinopathy: a critical review

KRN Brodeur, A Herculano… - Pathogens and Global …, 2023 - Taylor & Francis
This review will provide a better understanding of a set of signs known as malarial
retinopathy. The discovery of this retinopathy in association with cerebral malaria is …