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Natural products for drug discovery in the 21st century: innovations for novel drug discovery
The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …
pathological conditions have been treated using plant-derived medicines. These medicines …
The role of natural products as sources of therapeutic agents for innovative drug discovery
Emerging threats to human health require a concerted effort in search of both preventive and
treatment strategies, placing natural products at the center of efforts to obtain new therapies …
treatment strategies, placing natural products at the center of efforts to obtain new therapies …
Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs
Small regulatory RNAs (sRNAs) regulate gene expression in bacteria. We designed
synthetic sRNAs to identify and modulate the expression of target genes for metabolic …
synthetic sRNAs to identify and modulate the expression of target genes for metabolic …
Cellular stress associated with aneuploidy
Aneuploidy, chromosome stoichiometry that deviates from exact multiples of the haploid
compliment of an organism, exists in eukaryotic microbes, several normal human tissues …
compliment of an organism, exists in eukaryotic microbes, several normal human tissues …
Engineering microbial biofuel tolerance and export using efflux pumps
Many compounds being considered as candidates for advanced biofuels are toxic to
microorganisms. This introduces an undesirable trade‐off when engineering metabolic …
microorganisms. This introduces an undesirable trade‐off when engineering metabolic …
Chromosomal duplication is a transient evolutionary solution to stress
Aneuploidy, an abnormal number of chromosomes, is a widespread phenomenon found in
unicellulars such as yeast, as well as in plants and in mammalians, especially in cancer …
unicellulars such as yeast, as well as in plants and in mammalians, especially in cancer …
Automated multiplex genome-scale engineering in yeast
Genome-scale engineering is indispensable in understanding and engineering
microorganisms, but the current tools are mainly limited to bacterial systems. Here we report …
microorganisms, but the current tools are mainly limited to bacterial systems. Here we report …
Most azole resistance mutations in the Candida albicans drug target confer cross-resistance without intrinsic fitness cost
Azole antifungals are the main drugs used to treat fungal infections. Amino acid substitutions
in the drug target Erg11 (Cyp51) are a common resistance mechanism in pathogenic yeasts …
in the drug target Erg11 (Cyp51) are a common resistance mechanism in pathogenic yeasts …
Systematic exploration of essential yeast gene function with temperature-sensitive mutants
Conditional temperature-sensitive (ts) mutations are valuable reagents for studying essential
genes in the yeast Saccharomyces cerevisiae. We constructed 787 ts strains, covering 497 …
genes in the yeast Saccharomyces cerevisiae. We constructed 787 ts strains, covering 497 …
[HTML][HTML] Proteome-scale movements and compartment connectivity during the eukaryotic cell cycle
Cell cycle progression relies on coordinated changes in the composition and subcellular
localization of the proteome. By applying two distinct convolutional neural networks on …
localization of the proteome. By applying two distinct convolutional neural networks on …