Dendritic cells have the ability to efficiently present internalized antigens on major
histocompatibility complex (MHC) I molecules. This process is termed cross-presentation …

Antigenic peptide-loaded MHC class II molecules (peptide–MHC class II) are constitutively
expressed on the surface of professional antigen-presenting cells (APCs), including …

Chimeric antigen receptor‐T (CAR‐T) cell immunotherapy has shown impressive clinical
outcomes for hematologic malignancies. However, its broader applications are challenged …

Antigen presentation is essential for establishing immune tolerance and for immune
responses against infectious disease and cancer. Although antigen presentation can be …

Virus-like particles (VLPs) have been shown to be strong activators of dendritic cells (DCs).
DCs are the most potent antigen presenting cells (APCs) and their activation prompts the …

The presentation of exogenous antigens on MHC class I molecules, known as cross-
presentation, is essential for the initiation of CD8+ T cell responses. In vivo, cross …

T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

Tumor-associated macrophage (TAM) phagocytic activity is emerging as a new mechanism
to harness for cancer treatment. Currently, many approaches are investigated at the …

Abstract Type 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of
many viral and tumor antigens to CD8+ T cells. cDC1 cells can be identified in mice and …

Recognition of microbial pathogens and dead cells and their phagocytic uptake by
specialized immune cells are essential to maintain host homeostasis. Phagosomes undergo …