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Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
G Musso, M Cassader, R Gambino - Nature reviews Drug discovery, 2016 - nature.com
Non-alcoholic fatty liver disease—the most common chronic liver disease—encompasses a
histological spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) …
histological spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) …
[HTML][HTML] Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases
Inflammation is associated with the development of diseases characterized by altered
nutrient metabolism. Although an acute inflammatory response is host-protective and …
nutrient metabolism. Although an acute inflammatory response is host-protective and …
Biomarkers of meat tenderness: present knowledge and perspectives in regards to our current understanding of the mechanisms involved
Biomarkers of the meat quality are of prime importance for meat industry, which has to satisfy
consumers' expectations and, for them, meat tenderness is and will remain the primary and …
consumers' expectations and, for them, meat tenderness is and will remain the primary and …
Novel role for the AnxA1-Fpr2/ALX signaling axis as a key regulator of platelet function to promote resolution of inflammation
Background: Ischemia reperfusion injury (I/RI) is a common complication of cardiovascular
diseases. Resolution of detrimental I/RI-generated prothrombotic and proinflammatory …
diseases. Resolution of detrimental I/RI-generated prothrombotic and proinflammatory …
Annexin-A1: therapeutic potential in microvascular disease
GSD Purvis, E Solito, C Thiemermann - Frontiers in immunology, 2019 - frontiersin.org
Annexin-A1 (ANXA1) was first discovered in the early 1980's as a protein, which mediates
(some of the) anti-inflammatory effects of glucocorticoids. Subsequently, the role of ANXA1 …
(some of the) anti-inflammatory effects of glucocorticoids. Subsequently, the role of ANXA1 …
Annexin A1 restores Aβ1‐42‐induced blood–brain barrier disruption through the inhibition of RhoA‐ROCK signaling pathway
JC Park, SH Baik, SH Han, HJ Cho, H Choi, HJ Kim… - Aging cell, 2017 - Wiley Online Library
The blood–brain barrier (BBB) is composed of brain capillary endothelial cells and has an
important role in maintaining homeostasis of the brain separating the blood from the …
important role in maintaining homeostasis of the brain separating the blood from the …
Annexins in translational research: hidden treasures to be found
S Schloer, D Pajonczyk, U Rescher - International journal of molecular …, 2018 - mdpi.com
The vertebrate annexin superfamily (AnxA) consists of 12 members of a calcium (Ca2+) and
phospholipid binding protein family which share a high structural homology. In kee** with …
phospholipid binding protein family which share a high structural homology. In kee** with …
[PDF][PDF] Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice
Annexin A1 (AnxA1) is an effector of the resolution of inflammation and is highly effective in
terminating acute inflammatory responses. However, its role in chronic settings is less …
terminating acute inflammatory responses. However, its role in chronic settings is less …
Co-administration of iron and bioavailable curcumin reduces levels of systemic markers of inflammation and oxidative stress in a placebo-controlled randomised study
Ferrous sulphate (FS) is widely used as an iron supplement to treat iron deficiency (ID), but
is known to induce inflammation causing gastric side-effects resulting in poor adherence to …
is known to induce inflammation causing gastric side-effects resulting in poor adherence to …
[HTML][HTML] Annexins in adipose tissue: novel players in obesity
Obesity and the associated comorbidities are a growing health threat worldwide. Adipose
tissue dysfunction, impaired adipokine activity, and inflammation are central to metabolic …
tissue dysfunction, impaired adipokine activity, and inflammation are central to metabolic …