The discovery of leptin changed the view of adipose tissue from that of a passive vessel that
stores fat to that of a dynamic endocrine organ that actively regulates behaviour and …

Connections between neurons can be mapped by acquiring and analysing electron
microscopic brain images. In recent years, this approach has been applied to chunks of …

Brains contain networks of interconnected neurons and so knowing the network architecture
is essential for understanding brain function. We therefore mapped the synaptic-resolution …

Multi-modal neuroimaging projects such as the Human Connectome Project (HCP) and UK
Biobank are advancing our understanding of human brain architecture, function …

The hemibrain connectome provides large-scale connectivity and morphology information
for the majority of the central brain of Drosophila melanogaster. Using this data set, we …

Animals display selective escape behaviors when faced with environmental threats.
Selection of the appropriate response by the underlying neuronal network is key to …

Neural circuits carry out complex computations that allow animals to evaluate food, select
mates, move toward attractive stimuli, and move away from threats. In insects, the …

When deciding what to eat, animals evaluate sensory information about food quality
alongside multiple ongoing internal states,,,,,,,,–. How internal states interact to alter …

Taste detection and hunger state dynamically regulate the decision to initiate feeding. To
study how context-appropriate feeding decisions are generated, we combined synaptic …

The mushroom body (MB) is a well-characterized associative memory structure within the
Drosophila brain. Analyzing MB connectivity using multiple approaches is critical for …