We aim to systematically review and meta-analyze the effectiveness and safety of
psychedelics [psilocybin, ayahuasca (active component DMT), LSD and MDMA] in treating …

Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

This multi-site, randomized, double-blind, confirmatory phase 3 study evaluated the efficacy
and safety of 3, 4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) versus …

Post-traumatic stress disorder (PTSD) presents a major public health problem for which
currently available treatments are modestly effective. We report the findings of a randomized …

There are few medications with demonstrated efficacy for the treatment of posttraumatic
stress disorder (PTSD). Treatment guidelines have unequivocally designated psychotherapy …

Lysergic acid diethylamide (LSD) is a classic psychedelic, 3, 4-
methylenedioxymethamphetamine (MDMA) is an empathogen, and d-amphetamine is a …

Recent clinical and preclinical evidence suggests that psychedelics and entactogens may
produce both rapid and sustained therapeutic effects across several indications. Currently …

Background After no research in humans for> 40 years, there is renewed interest in using
lysergic acid diethylamide (LSD) in clinical psychiatric research and practice. There are no …

Unsuccessfully treated posttraumatic stress disorder (PTSD) is a serious and life-threatening
disorder. Two medications, paroxetine hydrochloride and sertraline hydrochloride, are …

Lysergic acid diethylamide (LSD) is used recreationally and has been evaluated as an
adjunct to psychotherapy to treat anxiety in patients with life-threatening illness. LSD is well …