Diversity, mechanisms, and significance of macrophage plasticity

M Locati, G Curtale, A Mantovani - Annual Review of Pathology …, 2020 - annualreviews.org
Macrophages are a diverse set of cells present in all body compartments. This diversity is
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …

Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies

S Paul, E Candelario-Jalil - Experimental neurology, 2021 - Elsevier
Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Macrophage polarization

PJ Murray - Annual review of physiology, 2017 - annualreviews.org
Macrophage polarization refers to how macrophages have been activated at a given point in
space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate …

Molecular mechanisms that influence the macrophage M1–M2 polarization balance

N Wang, H Liang, K Zen - Frontiers in immunology, 2014 - frontiersin.org
As an essential component of innate immunity, macrophages have multiple functions in both
inhibiting or promoting cell proliferation and tissue repair. Diversity and plasticity are …

Microglial and macrophage polarization—new prospects for brain repair

X Hu, RK Leak, Y Shi, J Suenaga, Y Gao… - Nature Reviews …, 2015 - nature.com
The traditional view of the adult brain as a static organ has changed in the past three
decades, with the emergence of evidence that it remains plastic and has some regenerative …

Role of human milk bioactives on infants' gut and immune health

LE Carr, MD Virmani, F Rosa, D Munblit… - Frontiers in …, 2021 - frontiersin.org
Exclusive human milk feeding of the newborn is recommended during the first 6 months of
life to promote optimal health outcomes during early life and beyond. Human milk contains a …

Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome

X Chen, J Tang, W Shuai, J Meng, J Feng, Z Han - Inflammation Research, 2020 - Springer
Purpose Macrophages are highly plastic cells. Under different stimuli, macrophages can be
polarized into several different subsets. Two main macrophage subsets have been …

[HTML][HTML] Monocyte and macrophage plasticity in tissue repair and regeneration

A Das, M Sinha, S Datta, M Abas, S Chaffee… - The American journal of …, 2015 - Elsevier
Heterogeneity and high versatility are the characteristic features of the cells of monocyte-
macrophage lineage. The mononuclear phagocyte system, derived from the bone marrow …

Targeting macrophages in cancer: from bench to bedside

AR Poh, M Ernst - Frontiers in oncology, 2018 - frontiersin.org
Macrophages are a major component of the tumor microenvironment and orchestrate
various aspects of immunity. Within tumors, macrophages can reversibly alter their endotype …

Roles of macrophage polarization and macrophage-derived miRNAs in pulmonary fibrosis

A Kishore, M Petrek - Frontiers in immunology, 2021 - frontiersin.org
This mini-review summarizes the current evidence for the role of macrophage activation and
polarization in inflammation and immune response pertinent to interstitial lung disease …