Beta-thalassemia (BTH), a recessively inherited haemoglobin (Hb) disorder, causes iron
overload (IO), extra-medullary haematopoiesis and bone marrow expansion with major …

Beta thalassemia is an inherited disorder resulting in abnormal or decreased production of
hemoglobin, leading to hemolysis and chronic anemia. The long-term complications can …

The procedure to diagnose anemia is time-consuming and resource-intensive due to the
existence of a multitude of symptoms that can be felt physically or seen visually. Anemia also …

Prime editing was used to insert and correct various pathogenic mutations except for beta-
thalassemia variants, which disrupt functional beta-globin and prevent hemoglobin …

Purpose Children living with thalassemia experience psychological challenges, but despite
significant psychosocial burdens, caregivers' psychological wellbeing and quality of life …

The success of transplant procedures in patients with beta-thalassemia major (β-
thalassemia) goes hand-in-hand with improvements in disease knowledge, better …

The antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione
peroxidase (GPx) and peroxiredoxin 2 (Prx2) are particularly important in erythroid cells …

Male infertility is defined as a failure to conceive after 12 months of unprotected intercourse
owing to suspected male reproductive factors. Non-malignant red blood cell disorders are …

Localized immunomodulation technologies are rapidly emerging as a new modality with the
potential to revolutionize transplantation of cells and organs. In the past decade, cell-based …

OBJECTIVE: β-thalassemia major is an inherited hematological disorder with significant
oxidative stress and iron overload. Oxidative stress results in several pathological …