Flavones: An important scaffold for medicinal chemistry

M Singh, M Kaur, O Silakari - European journal of medicinal chemistry, 2014 - Elsevier
Flavones have antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl
cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular …

CD36 and macrophages in atherosclerosis

S Collot-Teixeira, J Martin… - Cardiovascular …, 2007 - academic.oup.com
CD36 is a multi-ligand scavenger receptor present on the surface of a number of cells such
as platelets, monocytes/macrophages, endothelial and smooth muscle cells. Monocyte …

Role of monocytes in atherogenesis

B Østerud, E Bjørklid - Physiological reviews, 2003 - journals.physiology.org
Østerud, Bjarne, and Eirik Bjørklid. Role of Monocytes in Atherogenesis. Physiol Rev 83:
1069-1112, 2003; 10.1152/physrev. 00005.2003.—This review focuses on the role of …

The biological potential of flavones

AK Verma, R Pratap - Natural product reports, 2010 - pubs.rsc.org
Covering: 1990 to 2009 Flavones are well known for their antioxidant activity, and are
unique in that they are present in the majority of fruits and vegetables. The majority of …

Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animals

K Takahashi, M Takeya, N Sakashita - Medical electron microscopy, 2002 - Springer
In atherosclerosis, macrophages are important for intracellular lipid accumulation and foam
cell formation. Monocytes respond to chemotactic factors, cytokines, and macrophage …

The atherogenic effect of excess methionine intake

AM Troen, E Lutgens, DE Smith… - Proceedings of the …, 2003 - National Acad Sciences
Methionine is the precursor of homocysteine, a sulfur amino acid intermediate in the
methylation and transsulfuration pathways. Elevated plasma homocysteine …

The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues

S Nourshargh, F Krombach… - Journal of leukocyte …, 2006 - academic.oup.com
Innate and adaptive immunological responses are accompanied by leukocyte adhesion to
the blood-vessel wall and their subsequent infiltration into the underlying tissues. In the …

[HTML][HTML] Flavones mitigate tumor necrosis factor-α-induced adhesion molecule upregulation in cultured human endothelial cells: role of nuclear factor-κB

JS Choi, YJ Choi, SH Park, JS Kang, YH Kang - The Journal of nutrition, 2004 - Elsevier
Flavones have been classified as anti-atherogenic agents that inhibit monocyte adhesion to
stimulated endothelium, possibly by blocking induction of cell adhesion molecules (CAM) …

Inflammation meets oxidation: NF-κB as a mediator of initial lesion development in atherosclerosis

O Kutuk, H Basaga - Trends in molecular medicine, 2003 - cell.com
Transcription factor nuclear factor-κB (NF-κB) and its target genes are involved in the
pathogenesis of atherosclerosis, in addition to many other diseases. Monocyte recruitment …

Protocatechuic aldehyde suppresses TNF-α-induced ICAM-1 and VCAM-1 expression in human umbilical vein endothelial cells

Z Zhou, Y Liu, AD Miao, SQ Wang - European journal of pharmacology, 2005 - Elsevier
Adhesion molecules, which play a crucial role in the development of atherogenesis, are
produced by endothelial cells following stimulation with various inflammatory cytokines. The …