Progressive multifocal leukoencephalopathy (PML) is a rare but often fatal brain disease
caused by reactivation of the polyomavirus JC. Knowledge of the characteristics of PML has …

Cerebrospinal fluid (CSF) analysis is a basic tool for diagnosis of neurological diseases.
Knowledge regarding blood–CSF barrier function (molecular flux/CSF flow theory) and …

Background Gut-selective blockade of lymphocyte trafficking by vedolizumab may constitute
effective treatment for ulcerative colitis. Methods We conducted two integrated randomized …

Background The efficacy of vedolizumab, an α4β7 integrin antibody, in Crohn's disease is
unknown. Methods In an integrated study with separate induction and maintenance trials …

This report updates and combines earlier versions of guidelines for the prevention and
treatment of opportunistic infections (OIs) in HIV-infected adults (ie, persons aged> 18 years) …

Molecular studies suggest that the simian polyomavirus SV40 is present in the human
population, possibly introduced in contaminated polio vaccine. However, no recent …

Although discovered over thirty years ago, many aspects of the epidemiology of BKV and
JCV in the general population, such as the source of infectious virus and the mode of …

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain
caused by the JC virus (JCV). PML usually occurs via reactivation of JCV when an immune …

Progressive multifocal leukoencephalopathy is caused by the JC polyomavirus (JCV) and is
one of the most feared complications of HIV-1 infection. Unlike other opportunistic infections …

JC polyomavirus (JCPyV) was the first of now 12 PyVs detected in humans, when in 1964,
PyV particles were revealed by electron microscopy in progressive multifocal …