Local delivery of macromolecules to treat diseases associated with the colon

A Bak, M Ashford, DJ Brayden - Advanced drug delivery reviews, 2018 - Elsevier
Current treatments for intestinal diseases including inflammatory bowel diseases, irritable
bowel syndrome, and colonic bacterial infections are typically small molecule oral dosage …

Efficacy of teduglutide for parenteral support reduction in patients with short bowel syndrome: a systematic review and meta-analysis

F Bioletto, C D'Eusebio, FD Merlo, U Aimasso… - Nutrients, 2022 - mdpi.com
Teduglutide has been described as an effective treatment for parenteral support (PS)
reduction in patients with short bowel syndrome (SBS). However, a quantitative summary of …

Engineering transplantable jejunal mucosal grafts using patient-derived organoids from children with intestinal failure

L Meran, I Massie, S Campinoti, AE Weston… - Nature medicine, 2020 - nature.com
Intestinal failure, following extensive anatomical or functional loss of small intestine, has
debilitating long-term consequences for children. The priority of patient care is to increase …

ESPEN guideline on chronic intestinal failure in adults–Update 2023

L Pironi, C Cuerda, PB Jeppesen, F Joly, C Jonkers… - Clinical Nutrition, 2023 - Elsevier
Background & aims In 2016, ESPEN published the guideline for Chronic Intestinal Failure
(CIF) in adults. An updated version of ESPEN guidelines on CIF due to benign disease in …

Safety and efficacy of teduglutide in pediatric patients with intestinal failure due to short bowel syndrome: a 24‐week, phase III study

SA Kocoshis, RJ Merritt, S Hill… - Journal of Parenteral …, 2020 - Wiley Online Library
Background This study evaluated the safety and efficacy of teduglutide in pediatric patients
with short bowel syndrome–associated intestinal failure (SBS‐IF). Methods A 24‐week …

Trends in pediatric intestinal failure: a multicenter, multinational study

D Gattini, AJ Roberts, PW Wales, SV Beath… - The Journal of …, 2021 - Elsevier
Objectives To assess the natural history and outcomes of children with intestinal failure in a
large, multicenter, geographically diverse contemporary cohort (2010-2015) from 6 pediatric …

Therapeutic potential of GLP-2 analogs in gastrointestinal disorders: current knowledge, nutritional aspects, and future perspectives

D Kounatidis, NG Vallianou, D Tsilingiris… - Current Nutrition …, 2022 - Springer
Abstract Purpose of Review Although Glucagon-like peptide (GLP)-1 receptor agonists have
been used for almost two decades in the treatment of diabetes mellitus type 2 and, lately, in …

Experience with teduglutide in pediatric short bowel syndrome: first real-life data

ER Boluda, SR Ferreiro, OM Moral… - Journal of Pediatric …, 2020 - journals.lww.com
Objectives: The aim of the study was to describe the experience with teduglutide of several
Spanish hospitals in pediatric patients with SBS (SBS). Methods: Seventeen pediatric …

Six-month outcomes of teduglutide treatment in adult patients with short bowel syndrome with chronic intestinal failure: A real-world French observational cohort study

F Joly, D Seguy, A Nuzzo, C Chambrier, P Beau… - Clinical Nutrition, 2020 - Elsevier
Background & aims Teduglutide, a GLP-2-analog, has proven effective in two placebo-
controlled studies in reducing parenteral support (PS) in patients with short bowel syndrome …

Experience with teduglutide treatment for short bowel syndrome in clinical practice

S Pevny, S Maasberg, A Rieger, M Karber, E Blüthner… - Clinical Nutrition, 2019 - Elsevier
Background & aims Teduglutide, a glucagon-like peptide 2 (GLP-2) analog, is an approved
medication specific for short bowel syndrome patients with chronic intestinal failure (SBS-IF) …