Exploring the dynamic interplay between cancer stem cells and the tumor microenvironment: implications for novel therapeutic strategies

YR Li, Y Fang, Z Lyu, Y Zhu, L Yang - Journal of Translational Medicine, 2023 - Springer
Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and
metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby …

Targeting cancer stem cell pathways for cancer therapy

L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Unveiling the connection: long-chain non-coding RNAs and critical signaling pathways in breast cancer

R Thapa, O Afzal, G Gupta, AA Bhat, WH Almalki… - … -Research and Practice, 2023 - Elsevier
Breast cancer is a complex and diverse condition that disrupts multiple signaling pathways
essential for cell proliferation, survival, and differentiation. Recently, the significant …

NAD+ metabolism, stemness, the immune response, and cancer

LE Navas, A Carnero - Signal transduction and targeted therapy, 2021 - nature.com
NAD+ was discovered during yeast fermentation, and since its discovery, its important roles
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …

Single‐cell RNA sequencing in breast cancer: understanding tumor heterogeneity and paving roads to individualized therapy

S Ding, X Chen, K Shen - Cancer Communications, 2020 - Wiley Online Library
Single‐cell RNA sequencing (scRNA‐seq) is a novel technology that allows transcriptomic
analyses of individual cells. During the past decade, scRNA‐seq sensitivity, accuracy, and …

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage

AM Cameron, A Castoldi, DE Sanin… - Nature …, 2019 - nature.com
The adoption of Warburg metabolism is critical for the activation of macrophages in
response to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase …

Carbon dots: a booming material for biomedical applications

W Su, H Wu, H Xu, Y Zhang, Y Li, X Li… - Materials Chemistry …, 2020 - pubs.rsc.org
As one of the most promising nanomaterials for biomedical applications, carbon dots (CDs)
hold great potential in the field of bioimaging, biosensing and biotherapy due to their low …

Dissecting tumor growth: the role of cancer stem cells in drug resistance and recurrence

B Aramini, V Masciale, G Grisendi, F Bertolini, M Maur… - Cancers, 2022 - mdpi.com
Simple Summary Cancer is one of the most debated problems all over the world. Cancer
stem cells are considered responsible of tumor initiation, metastasis, drug resistance, and …

Cancer stem cell signaling pathways

WH Matsui - Medicine, 2016 - journals.lww.com
Tissue development and homeostasis are governed by the actions of stem cells. Multipotent
cells are capable of self-renewal during the course of one's lifetime. The accurate and …

Ultrasound-responsive nanocarriers in cancer treatment: A review

NS Awad, V Paul, NM AlSawaftah… - ACS Pharmacology & …, 2021 - ACS Publications
The safe and effective delivery of anticancer agents to diseased tissues is one of the
significant challenges in cancer therapy. Conventional anticancer agents are generally …