Maternal microbiota, early life colonization and breast milk drive immune development in the newborn

C Kalbermatter, N Fernandez Trigo… - Frontiers in …, 2021‏ - frontiersin.org
The innate immune system is the oldest protection strategy that is conserved across all
organisms. Although having an unspecific action, it is the first and fastest defense …

Preterm birth and sustained inflammation: consequences for the neonate

A Humberg, I Fortmann, B Siller, MV Kopp… - Seminars in …, 2020‏ - Springer
Almost half of all preterm births are caused or triggered by an inflammatory process at the
feto-maternal interface resulting in preterm labor or rupture of membranes with or without …

A randomized synbiotic trial to prevent sepsis among infants in rural India

P Panigrahi, S Parida, NC Nanda, R Satpathy… - Nature, 2017‏ - nature.com
Sepsis in early infancy results in one million annual deaths worldwide, most of them in
develo** countries. No efficient means of prevention is currently available. Here we report …

[PDF][PDF] Neonatal sepsis

IO Odabasi, A Bulbul - Şişli Etfal Hastanesi Tip Bülteni, 2020‏ - jag.journalagent.com
Neonatal sepsis is associated with severe morbidity and mortality in the neonatal period.
Clinical manifestations range from subclinical infection to severe local or systemic infection …

Late-onset neonatal sepsis: recent developments

Y Dong, CP Speer - Archives of Disease in Childhood-Fetal and …, 2015‏ - fn.bmj.com
The incidence of neonatal late-onset sepsis (LOS) is inversely related to the degree of
maturity and varies geographically from 0.61% to 14.2% among hospitalised newborns …

Neonatal sepsis of early onset, and hospital-acquired and community-acquired late onset: a prospective population-based cohort study

E Giannoni, PKA Agyeman, M Stocker… - The Journal of …, 2018‏ - Elsevier
Objective To assess the epidemiology of blood culture-proven early-(EOS) and late-onset
neonatal sepsis (LOS). Study design All newborn infants admitted to tertiary care neonatal …

Gut pathogen colonization precedes bloodstream infection in the neonatal intensive care unit

DJ Schwartz, N Shalon, K Wardenburg… - Science translational …, 2023‏ - science.org
Bacterial bloodstream infections (BSIs) resulting in late-onset sepsis affect up to half of
extremely preterm infants and have substantial morbidity and mortality. Bacterial species …

Updates in late-onset sepsis: risk assessment, therapy, and outcomes

SA Coggins, K Glaser - Neoreviews, 2022‏ - publications.aap.org
Neonatal late-onset sepsis (LOS) continues to threaten morbidity and mortality in the NICU
and poses ongoing diagnostic and therapeutic challenges. Early recognition of clinical …

Biomarkers of neonatal sepsis: where we are and where we are going

G Boscarino, R Migliorino, G Carbone, G Davino… - Antibiotics, 2023‏ - mdpi.com
Neonatal sepsis is a bacterial bloodstream infection leading to severe clinical manifestations
frequently associated with death or irreversible long-term deficits. Antibiotics are the drug of …

Challenges in develo** a consensus definition of neonatal sepsis

M McGovern, E Giannoni, H Kuester, MA Turner… - Pediatric …, 2020‏ - nature.com
Sepsis remains a leading cause of morbidity and mortality in the neonatal population, and at
present, there is no unified definition of neonatal sepsis. Existing consensus sepsis …