Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases

S Wang, B Liang, W Wang, L Li, N Feng… - Signal transduction and …, 2023 - nature.com
Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …

Post-exposure treatments for Ebola and Marburg virus infections

RW Cross, CE Mire, H Feldmann… - Nature Reviews Drug …, 2018 - nature.com
The filoviruses—Ebola virus and Marburg virus—cause lethal haemorrhagic fever in
humans and non-human primates (NHPs). Filoviruses present a global health threat both as …

Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever

T Abreu-Mota, KR Hagen, K Cooper… - Nature …, 2018 - nature.com
Lassa fever (LF), caused by Lassa virus (LASV), is a viral hemorrhagic fever for which no
approved vaccine or potent antiviral treatment is available. LF is a WHO priority disease and …

Ebola and Marburg virus vaccines

P Reynolds, A Marzi - Virus Genes, 2017 - Springer
The filoviruses, Ebola virus (EBOV), and Marburg virus (MARV), are among the most
pathogenic viruses known to man and the causative agents of viral hemorrhagic fever …

Advances in designing and develo** vaccines, drugs, and therapies to counter Ebola virus

K Dhama, K Karthik, R Khandia, S Chakraborty… - Frontiers in …, 2018 - frontiersin.org
Ebola virus (EBOV), a member of the family Filoviridae, is responsible for causing Ebola
virus disease (EVD)(formerly named Ebola hemorrhagic fever). This is a severe, often fatal …

Animal models of ebolavirus infection

MC St Claire, DR Ragland, L Bollinger… - Comparative …, 2017 - ingentaconnect.com
Ebola virus is a highly pathogenic member of the family Filoviridae that causes a severe
hemorrhagic disease in humans and NHP. The 2013–2016 West African outbreak has …

Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model

D Kurup, DC Malherbe, C Wirblich, R Lambert… - PLoS …, 2021 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent
coronavirus that has caused a worldwide pandemic. Although human disease is often …

Ebola: lessons on vaccine development

H Feldmann, F Feldmann, A Marzi - Annual review of …, 2018 - annualreviews.org
The West African Ebola virus (EBOV) epidemic has fast-tracked countermeasures for this
rare, emerging zoonotic pathogen. Until 2013–2014, most EBOV vaccine candidates were …

[HTML][HTML] Monophosphoryl-lipid A (MPLA) is an efficacious adjuvant for inactivated rabies vaccines

C Chen, C Zhang, R Li, Z Wang, Y Yuan, H Li, Z Fu… - Viruses, 2019 - mdpi.com
Rabies, as one of the most threatening zoonoses in the world, causes a fatal central nervous
system (CNS) disease. So far, vaccination with rabies vaccines has been the most effective …

Rabies virus-based COVID-19 vaccine CORAVAX™ induces high levels of neutralizing antibodies against SARS-CoV-2

D Kurup, C Wirblich, H Ramage, MJ Schnell - npj Vaccines, 2020 - nature.com
The recently emerged coronavirus SARS-CoV-2, the causative agent of COVID-19, is rapidly
spreading in the world. The exponentially expanding threat of SARS-CoV-2 to global health …