Neurodegenerative diseases affect millions of people worldwide. Neurodegenerative
diseases result from progressive damage to nerve cells in the brain or peripheral nervous …

G protein-coupled receptors (GPCRs) are the most common proteins targeted by approved
drugs. A complete mechanistic elucidation of large-scale conformational transitions …

The endocannabinoid system (ECS) comprises two cognate endocannabinoid receptors
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …

Gq proteins are universally important for signal transduction in mammalian cells. The
underlying kinetics and transformation from extracellular stimuli into intracellular signaling …

As the key governors of diverse physiological processes, G protein-coupled receptors
(GPCRs) have drawn attention as primary targets for several diseases, including diabetes …

GPR35 is a G protein-coupled receptor with notable involvement in modulating inflammatory
responses. Although the precise role of GPR35 in inflammation is not yet fully understood …

Antipsychotics are commonly used in treating psychiatric disorders. These medications
primarily target dopamine the serotonin receptors, they have some affinity to adrenergic …

Efficient Ca 2+ flux induced during cognate T cell activation requires signaling the T cell
receptor (TCR) and unidentified G-protein-coupled receptors (GPCRs). T cells express the …

GNA 13 has been found overexpressed in various types of cancer, which is related to tumor
metastasis and progression. However, the biological functions of GNA 13 in colorectal …

One of the most important goals in the treatment of demyelinating diseases such as multiple
sclerosis (MS) is, in addition to immunomodulation, reconstruction of the lost myelin sheath …