Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Structural and functional architecture of AMPA-type glutamate receptors and their auxiliary proteins
AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
AMPA receptor trafficking and synaptic plasticity
▪ Abstract Activity-dependent changes in synaptic function are believed to underlie the
formation of memories. Two prominent examples are long-term potentiation (LTP) and long …
formation of memories. Two prominent examples are long-term potentiation (LTP) and long …
[HTML][HTML] Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach
The precise subunit composition of synaptic ionotropic receptors in the brain is poorly
understood. This information is of particular importance with regard to AMPA-type glutamate …
understood. This information is of particular importance with regard to AMPA-type glutamate …
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Stargazer, an ataxic and epileptic mutant mouse, lacks functional AMPA (α-amino-3-
hydroxyl-5-methyl-4-isoxazolepropionate) receptors on cerebellar granule cells. Stargazin …
hydroxyl-5-methyl-4-isoxazolepropionate) receptors on cerebellar granule cells. Stargazin …
Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number
E Schnell, M Sizemore… - Proceedings of the …, 2002 - National Acad Sciences
Excitatory synapses in the brain exhibit a remarkable degree of functional plasticity, which
largely reflects changes in the number of synaptic α-amino-3-hydroxy-5-methyl-4 …
largely reflects changes in the number of synaptic α-amino-3-hydroxy-5-methyl-4 …
[HTML][HTML] The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits
AC Jackson, RA Nicoll - Neuron, 2011 - cell.com
Ionotropic glutamate receptors (iGluRs) underlie rapid, excitatory synaptic signaling
throughout the CNS. After years of intense research, our picture of iGluRs has evolved from …
throughout the CNS. After years of intense research, our picture of iGluRs has evolved from …
Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins
Functional expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors in cerebellar granule cells requires stargazin, a member of a large family of four …
receptors in cerebellar granule cells requires stargazin, a member of a large family of four …
Neural substrates of eyeblink conditioning: acquisition and retention
KM Christian, RF Thompson - Learning & memory, 2003 - learnmem.cshlp.org
Classical conditioning of the eyeblink reflex to a neutral stimulus that predicts an aversive
stimulus is a basic form of associative learning. Acquisition and retention of this learned …
stimulus is a basic form of associative learning. Acquisition and retention of this learned …