Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis of 1H-magnetic resonance spectroscopy studies
Abstract Background The glutamate (Glu) and gamma aminobutyric acid (GABA)
hypotheses of schizophrenia were proposed in the 1980s. However, current findings on …
hypotheses of schizophrenia were proposed in the 1980s. However, current findings on …
Glutamatergic dysfunction in Schizophrenia
AO Kruse, JR Bustillo - Translational Psychiatry, 2022 - nature.com
The NMDA-R hypofunction model of schizophrenia started with the clinical observation of
the precipitation of psychotic symptoms in patients with schizophrenia exposed to PCP or …
the precipitation of psychotic symptoms in patients with schizophrenia exposed to PCP or …
Association of age, antipsychotic medication, and symptom severity in schizophrenia with proton magnetic resonance spectroscopy brain glutamate level: a mega …
Importance Proton magnetic resonance spectroscopy (1H-MRS) studies indicate that altered
brain glutamatergic function may be associated with the pathophysiology of schizophrenia …
brain glutamatergic function may be associated with the pathophysiology of schizophrenia …
Changes in brain glutamate on switching to clozapine in treatment-resistant schizophrenia
It has been suggested that the antipsychotic clozapine may modulate brain glutamate, and
that this effect could contribute to its efficacy in treatment-resistant schizophrenia (TRS). The …
that this effect could contribute to its efficacy in treatment-resistant schizophrenia (TRS). The …
A meta-analysis of ultra-high field glutamate, glutamine, GABA and glutathione 1HMRS in psychosis: Implications for studies of psychosis risk
Ultra-high field proton magnetic resonance spectroscopy (1 HMRS) offers a unique
opportunity to measure the concentration of neurometabolites implicated in psychosis (PSY) …
opportunity to measure the concentration of neurometabolites implicated in psychosis (PSY) …
Anterior cingulate glutamate metabolites as a predictor of antipsychotic response in first episode psychosis: data from the STRATA collaboration
A Egerton, K Griffiths, C Casetta, B Deakin… - …, 2023 - nature.com
Elevated brain glutamate has been implicated in non-response to antipsychotic medication
in schizophrenia. Biomarkers that can accurately predict antipsychotic non-response from …
in schizophrenia. Biomarkers that can accurately predict antipsychotic non-response from …
Disrupted subcortical functional connectome gradient in drug-naïve first-episode schizophrenia and the normalization effects after antipsychotic treatment
Antipsychotics are thought to improve schizophrenia symptoms through the antagonism of
dopamine D2 receptors, which are abundant mainly in subcortical regions. By introducing …
dopamine D2 receptors, which are abundant mainly in subcortical regions. By introducing …
[HTML][HTML] Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality …
Background Brain metabolite abnormalities measured with magnetic resonance
spectroscopy (MRS) provide insight into pathological processes in schizophrenia. Prior meta …
spectroscopy (MRS) provide insight into pathological processes in schizophrenia. Prior meta …
[HTML][HTML] Medial prefrontal cortex glutamate is reduced in schizophrenia and moderated by measurement quality: a meta-analysis of proton magnetic resonance …
Background Magnetic resonance spectroscopy studies measuring brain glutamate
separately from glutamine are hel** elucidate schizophrenia pathophysiology. An …
separately from glutamine are hel** elucidate schizophrenia pathophysiology. An …
Neurobiology and applications of inositol in psychiatry: a narrative review
C Concerto, C Chiarenza, A Di Francesco… - Current Issues in …, 2023 - mdpi.com
Inositol is a natural sugar-like compound, commonly present in many plants and foods. It is
involved in several biochemical pathways, most of them controlling vital cellular …
involved in several biochemical pathways, most of them controlling vital cellular …