Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

Acinetobacter baumannii has emerged as a highly troublesome pathogen for many
institutions globally. As a consequence of its immense ability to acquire or upregulate …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

EXECUTIVE SUMMARY Since the initial 1996 American Thoracic Society (ATS) guideline
on nosocomial pneumonia, a number of new developments have appeared, mandating a …

Being a multidrug-resistant and an invasive pathogen, Acinetobacter baumannii is one of
the major causes of nosocomial infections in the current healthcare system. It has been …

Since the 1970s, the spread of multidrug-resistant (MDR) Acinetobacter strains among
critically ill, hospitalized patients, and subsequent epidemics, have become an increasing …

The emergence of multidrug-resistant gram-negative bacteria and the lack of new antibiotics
to combat them have led to the revival of polymyxins, an old class of cationic, cyclic …

Background The β-lactamase inhibitor relebactam can restore imipenem activity against
imipenem-nonsusceptible gram-negative pathogens. We evaluated imipenem/relebactam …

We may soon be facing the end of the “antibiotic era.” The initial and seemingly unstoppable
success of antibiotics, the fruit of human ingenuity, has been countered by an escalation of …

Antibiotic resistance is the most challenging clinical and public health problem. Despite of
living in the era of novel technologies in biomedical research, many of untreatable infectious …