Epileptogenic networks are defined by the brain regions involved in the production and
propagation of epileptic activities. In this review we describe the historical, methodologic …

Ongoing challenges in diagnosing focal cortical dysplasia (FCD) mandate continuous
research and consensus agreement to improve disease definition and classification. An …

Identification and localization of the “epileptogenic process” in the brain of patients with drug-
resistant epilepsy for surgical cure is the goal of presurgical investigations. Intracranial …

Defining a bio-electrical marker for the brain area responsible for initiating a seizure remains
an unsolved problem. Fast gamma activity has been identified as the most specific marker …

Drug-refractory focal epilepsies are network diseases associated with functional connectivity
alterations both during ictal and interictal periods. A large majority of studies on the …

Objective In this study, we seek to analyze the determinants of the intracranial
electroencephalography seizure onset pattern (SOP) and the impact of the SOP in predicting …

Seizures are a disruption of normal brain activity present across a vast range of species and
conditions. We introduce an organizing principle that leads to the first objective Taxonomy of …

Objective To determine the involvement of subcortical regions in human epilepsy by
analyzing direct recordings from these regions during epileptic seizures using stereo-EEG …

Patients with drug-resistant epilepsy often require surgery to become seizure-free. While
laser ablation and implantable stimulation devices have lowered the morbidity of these …

Single-unit recordings performed in temporal lobe epilepsy patients and in models of
temporal lobe seizures have shown that interneurons are active at focal seizure onset. We …