New developments in RiPP discovery, enzymology and engineering
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
Fungal secondary metabolism: regulation, function and drug discovery
NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation
Microorganisms produce small bioactive compounds as part of their secondary or
specialised metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal …
specialised metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal …
antiSMASH 6.0: improving cluster detection and comparison capabilities
K Blin, S Shaw, AM Kloosterman… - Nucleic acids …, 2021 - academic.oup.com
Many microorganisms produce natural products that form the basis of antimicrobials,
antivirals, and other drugs. Genome mining is routinely used to complement screening …
antivirals, and other drugs. Genome mining is routinely used to complement screening …
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline
K Blin, S Shaw, K Steinke, R Villebro… - Nucleic acids …, 2019 - academic.oup.com
Secondary metabolites produced by bacteria and fungi are an important source of
antimicrobials and other bioactive compounds. In recent years, genome mining has seen …
antimicrobials and other bioactive compounds. In recent years, genome mining has seen …
A new genomic blueprint of the human gut microbiota
The composition of the human gut microbiota is linked to health and disease, but knowledge
of individual microbial species is needed to decipher their biological roles. Despite …
of individual microbial species is needed to decipher their biological roles. Despite …
The amazing potential of fungi: 50 ways we can exploit fungi industrially
Fungi are an understudied, biotechnologically valuable group of organisms. Due to the
immense range of habitats that fungi inhabit, and the consequent need to compete against a …
immense range of habitats that fungi inhabit, and the consequent need to compete against a …
IMG/M v. 5.0: an integrated data management and comparative analysis system for microbial genomes and microbiomes
Abstract The Integrated Microbial Genomes & Microbiomes system v. 5.0 (IMG/M: https://img.
jgi. doe. gov/m/) contains annotated datasets categorized into: archaea, bacteria, eukarya …
jgi. doe. gov/m/) contains annotated datasets categorized into: archaea, bacteria, eukarya …
A new antibiotic selectively kills Gram-negative pathogens
The current need for novel antibiotics is especially acute for drug-resistant Gram-negative
pathogens,. These microorganisms have a highly restrictive permeability barrier, which limits …
pathogens,. These microorganisms have a highly restrictive permeability barrier, which limits …
US immigration westernizes the human gut microbiome
Many US immigrant populations develop metabolic diseases post immigration, but the
causes are not well understood. Although the microbiome plays a role in metabolic disease …
causes are not well understood. Although the microbiome plays a role in metabolic disease …