[HTML][HTML] Silica nanoparticles: Biomedical applications and toxicity

Y Huang, P Li, R Zhao, L Zhao, J Liu, S Peng… - Biomedicine & …, 2022 - Elsevier
Silica nanoparticles (SiNPs) are composed of silicon dioxide, the most abundant compound
on Earth, and are used widely in many applications including the food industry, synthetic …

Overcoming blood–brain barrier transport: Advances in nanoparticle-based drug delivery strategies

S Ding, AI Khan, X Cai, Y Song, Z Lyu, D Du, P Dutta… - Materials today, 2020 - Elsevier
The blood–brain barrier (BBB), a unique structure in the central nervous system (CNS),
protects the brain from bloodborne pathogens by its excellent barrier properties …

Inorganic nano-drug delivery systems for crossing the blood–brain barrier: Advances and challenges

Q Tan, S Zhao, T Xu, Q Wang, M Zhang, L Yan… - Coordination Chemistry …, 2023 - Elsevier
The blood–brain barrier (BBB) exists between plasma and brain tissue. It comprises a
capillary wall and glial cells and prevents external substances, including therapeutic agents …

Oxidative stress modulating nanomaterials and their biochemical roles in nanomedicine

KD Patel, Z Keskin-Erdogan, P Sawadkar… - Nanoscale …, 2024 - pubs.rsc.org
Many pathological conditions are predominantly associated with oxidative stress, arising
from reactive oxygen species (ROS); therefore, the modulation of redox activities has been a …

Blood-brain delivery methods using nanotechnology

DM Teleanu, C Chircov, AM Grumezescu, A Volceanov… - Pharmaceutics, 2018 - mdpi.com
Pathologies of the brain, of which brain cancer, Alzheimer's disease, Parkinson's disease,
stroke, and multiple sclerosis, are some of the most prevalent, and that presently are poorly …

Functionalized nanomaterials capable of crossing the blood–brain barrier

S Zha, H Liu, H Li, H Li, KL Wong, AH All - ACS nano, 2024 - ACS Publications
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly
regulates exchanges between the central nervous system parenchyma and blood vessels …

Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: An update

RR Castillo, D Lozano, B González… - Expert opinion on …, 2019 - Taylor & Francis
ABSTRACT Introduction Mesoporous silica nanoparticles (MSNs) are outstanding
nanoplatforms for drug delivery. Herein, the most recent advances to turn MSN-based …

Multifunctional polymeric nanoplatforms for brain diseases diagnosis, therapy and theranostics

S Shakeri, M Ashrafizadeh, A Zarrabi, R Roghanian… - Biomedicines, 2020 - mdpi.com
The blood–brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS)
from damage by substances that originate from the blood circulation. The BBB limits drug …

Resveratrol brain delivery for neurological disorders prevention and treatment

S Andrade, MJ Ramalho, MC Pereira… - Frontiers in …, 2018 - frontiersin.org
Resveratrol (RES) is a natural polyphenolic non-flavonoid compound present in grapes,
mulberries, peanuts, rhubarb and in several other plants. Numerous health effects have …

Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases

WC Ballance, EC Qin, HJ Chung, MU Gillette, H Kong - Biomaterials, 2019 - Elsevier
Neurodegenerative diseases and disorders seriously impact memory and cognition and can
become life-threatening. Current medical techniques attempt to combat these detrimental …