Amyloid β protein and Alzheimer's disease: When computer simulations complement experimental studies
Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
Aβ oligomers–a decade of discovery
Converging lines of evidence suggest that progressive accumulation of the amyloid β‐
protein (Aβ) plays a central role in the genesis of Alzheimer's disease, but it was long …
protein (Aβ) plays a central role in the genesis of Alzheimer's disease, but it was long …
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease
Reduction of amyloid beta (Aβ) has been shown to be effective in treating Alzheimer's
disease (AD), but the underlying assumption that neurons are the main source of pathogenic …
disease (AD), but the underlying assumption that neurons are the main source of pathogenic …
Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins
MP Lambert, AK Barlow, BA Chromy… - Proceedings of the …, 1998 - National Acad Sciences
Aβ1–42 is a self-associating peptide whose neurotoxic derivatives are thought to play a role
in Alzheimer's pathogenesis. Neurotoxicity of amyloid β protein (Aβ) has been attributed to …
in Alzheimer's pathogenesis. Neurotoxicity of amyloid β protein (Aβ) has been attributed to …
High-level neuronal expression of Aβ1–42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation
L Mucke, E Masliah, GQ Yu, M Mallory… - Journal of …, 2000 - Soc Neuroscience
Amyloid plaques are a neuropathological hallmark of Alzheimer's disease (AD), but their
relationship to neurodegeneration and dementia remains controversial. In contrast, there is …
relationship to neurodegeneration and dementia remains controversial. In contrast, there is …
Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid …
JD Harper, PT Lansbury Jr - Annual review of biochemistry, 1997 - annualreviews.org
Ordered protein aggregation in the brain is a hallmark of Alzheimer's disease and scrapie.
The disease-specific amyloid fibrils comprise primarily a single protein, amyloid β, in …
The disease-specific amyloid fibrils comprise primarily a single protein, amyloid β, in …
Amyloid oligomers: formation and toxicity of Aβ oligomers
Alzheimer's disease (AD) is an age‐related, progressive degenerative disorder that is
characterized by synapse and neuron loss in the brain and the accumulation of protein …
characterized by synapse and neuron loss in the brain and the accumulation of protein …
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
The amyloid peptides Aβ40 and Aβ42 of Alzheimer's disease are thought to contribute
differentially to the disease process. Although Aβ42 seems more pathogenic than Aβ40, the …
differentially to the disease process. Although Aβ42 seems more pathogenic than Aβ40, the …
[HTML][HTML] Alzheimer's amyloid fibrils: structure and assembly
LC Serpell - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2000 - Elsevier
Structural studies of Alzheimer's amyloid fibrils have revealed information about the structure
at different levels. The amyloid-β peptide has been examined in various solvents and …
at different levels. The amyloid-β peptide has been examined in various solvents and …
In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis
WB Stine, KN Dahlgren, GA Krafft, MJ LaDu - Journal of Biological …, 2003 - ASBMB
Extensive research causally links amyloid-β peptide (Aβ) to Alzheimer's disease, although
the pathologically relevant Aβ conformation remains unclear. Aβ spontaneously aggregates …
the pathologically relevant Aβ conformation remains unclear. Aβ spontaneously aggregates …