Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …

Almost two decades after the identification of SNCA as the first causative gene in
Parkinson's disease (PD) and the subsequent understanding that genetic factors play a …

Since the first formal description of Parkinson disease (PD) two centuries ago, our
understanding of this common neurodegenerative disorder has expanded at all levels of …

Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the
substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic …

Parkinson's disease (PD) is a complex disorder with many different causes, yet they may
intersect in common pathways, raising the possibility that neuroprotective agents may have …

A broad range of neurodegenerative disorders is characterized by neuronal damage that
may be caused by toxic, aggregation-prone proteins. As genes are identified for these …

Gene defects play a major role in the pathogenesis of degenerative disorders of the nervous
system. In fact, it has been the very knowledge gained from genetic studies that has allowed …

Less than a quarter century after the discovery of SNCA as the first attributable gene in
Parkinson's disease (PD), our knowledge of the genetic architecture underlying this disease …

Abstract Glycogen synthase kinase 3 (GSK-3) dysregulation plays an important role in the
pathogenesis of numerous disorders, affecting the central nervous system (CNS) …

Parkinson disease (PD) and Parkinson-plus syndromes are genetically heterogeneous
neurological diseases. Initial studies into the genetic causes of PD relied on classical …