For much of the past century, drug discovery relied largely on the use of animal models of
disease as the first-line screens for testing the compounds produced by medicinal chemists …

Dual COX/5-LOX (cyclooxygenase/5-lipoxygenase) inhibitors constitute a valuable
alternative to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …

Background Resveratrol (RVL) is a polyphenol-containing natural product found in a variety
of plants, including peanuts, grapes, and berry fruits. The use of RVL is linked in a great deal …

Aberrant arachidonic acid metabolism is involved in the inflammatory and carcinogenic
processes. In this study, we investigated the effects of curcumin, a naturally occurring …

Inflammatory mediators of the arachidonic acid cascade from cyclooxygenase (COX) and
lipoxygenase (LOX) pathways are primarily responsible for many diseases in human beings …

Inflammation is a natural process that is connected to various conditions and disorders such
as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase …

Inflammation is a most complex pathological process that gives birth to different diseases.
Different inflammatory mediators are released during an inflammation responsible for acute …

A series of novel 8/10-trifluoromethyl-substituted-imidazo [1, 2-c] quinazolines have been
synthesized and evaluated in vivo (rat paw edema) for their anti-inflammatory activity and in …

In the current study, a series of new (2 S, 3 S)-2-(4-isopropylbenzyl)-2-methyl-4-nitro-3-
phenylbutanals (FM1-6) with their corresponding carboxylic acid analogues (FM7-12) has …

New anti-inflammatory agents possessing dual cyclooxygenase/lipoxygenase (COX/LOX)
inhibition were discovered by computer-aided prediction of biological activity for 573 virtually …