Tumor microenvironment (TME) is characterized by mutual interactions of the tumor, stromal
and immune cells. Early and advanced colorectal tumors differ in structure and present …

Myeloid-derived suppressor cells (MDSCs) are a group of immature myeloid cells, which are
expanded in most cancer patients. MDSCs suppress host immune responses, leading to …

Severe immunosuppression is a hallmark of colorectal cancer (CRC). Myeloid-derived
suppressor cells (MDSCs), one of the most abundant components of the tumor stroma, play …

Despite the clinical outcomes being extremely limited, blocking immune inhibitory
checkpoint pathways has been in the spotlight as a promising strategy for treating …

In recent decades, immunometabolism in cancers has emerged as an interesting target for
treatment development. Indeed, the tumor microenvironment (TME) unique characteristics …

Coronavirus disease 2019 (COVID‐19) has been raised as a pandemic disease since
December 2019. Immunosuppressive cells including T regulatory cells (Tregs) and myeloid …

For a long time, myeloid-derived suppressor cells (MDSCs) dilated in circulation system of
colorectal cancer (CRC) patients have been puzzling clinicians. Various evidence shows …

Elevated levels of myeloid-derived suppressor cells (MDSCs), including polymorphonuclear
MDSCs (PMN-MDSCs) and immature MDSCs (I-MDSCs), are usually associated with …

Cancer immunotherapies, such as immune checkpoint inhibitors (ICIs), have revolutionized
the treatment of various cancers and have shown a great efficacy in inducing antitumor …

The tumour microenvironment (TME) nurtures a tolerant microenvironment consisting of
various immunosuppressive factors, which thwart potent anti-tumour immune responses to …