In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

Posttraumatic stress disorder can be viewed as a disorder of fear dysregulation. An
abundance of research suggests that the prefrontal cortex is central to fear processing—that …

Aberrations in the epigenetic landscape are a hallmark of cancer. Alterations in enzymes
that are “writers,”“erasers,” or “readers” of histone modification marks are common …

Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …

Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto
lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors …

Fear conditioning and fear extinction are Pavlovian conditioning paradigms extensively
used to study the mechanisms that underlie learning and memory formation. The neural …

Epigenetic mechanisms control various functions throughout the body, from cell fate
determination in development to immune responses and inflammation. Neuroinflammation …

5-hydroxymethylcytosine (5-hmC) is a novel DNA modification that is highly enriched in the
adult brain and dynamically regulated by neural activity. 5-hmC accumulates across the …

Ageing is the main risk factor for human neurological disorders. Among the diverse
molecular pathways that govern ageing, epigenetics can guide age-associated decline in …

The capacity to remember our past experiences and organize our future draws on a number
of cognitive processes that allow our brain to form and store neural representations that can …