This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …

DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …

The concept of 'lifestyle 'includes different factors such as nutrition, behavior, stress, physical
activity, working habits, smoking and alcohol consumption. Increasing evidence shows that …

Cancer-associated DNA hypomethylation is as prevalent as cancer-linked hypermethylation,
but these two types of epigenetic abnormalities usually seem to affect different DNA …

Folate is a cofactor in one-carbon metabolism, during which it promotes the remethylation of
homocysteine–a cytotoxic sulfur-containing amino acid that can induce DNA strand …

Colorectal cancer is a complex disease resulting from somatic genetic and epigenetic
alterations, including locus-specific CpG island methylation and global DNA or LINE-1 …

ContextLaboratory and epidemiological data suggest that folic acid may have an
antineoplastic effect in the large intestine. ObjectiveTo assess the safety and efficacy of folic …

Epidemiological data have identified chronic alcohol consumption as a significant risk factor
for upper alimentary tract cancer, including cancer of the oropharynx, larynx and the …

This study was designed to determine if maternal dietary methyl supplements increase DNA
methylation and methylation-dependent epigenetic phenotypes in mammalian offspring …

More than 18 million adults in the United States abuse alcohol, a prevalence 5 times higher
than that of hepatitis C. Chronic alcohol use of greater than 80 g/day for more than 10 years …