Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

Atrial fibrillation (AF) is the most common cardiac arrhythmia. AF increases the risk of stroke,
heart failure, dementia, and hospitalization. Obesity significantly increases AF risk, both …

In recent years, SGLT2 inhibitors have become an integral part of heart failure therapy, and
several mechanisms contributing to cardiorenal protection have been identified. In this …

Aims Short QT syndrome type 3 (SQTS3) is a rare arrhythmogenic disease caused by gain-
of-function mutations in KCNJ2, the gene coding the inward rectifier potassium channel Kir2 …

Generating atrial-like cardiomyocytes derived from human induced pluripotent stem cells
(hiPSCs) is crucial for modeling and treating atrial-related diseases, such as atrial …

Intracellular electrophysiology is essential in neuroscience, cardiology, and pharmacology
for studying cells' electrical properties. Traditional methods like patch-clamp are precise but …

Background Propagation of action potentials through the heart coordinates the heartbeat.
Thus, intercalated discs, specialized cell–cell contact sites that provide electrical and …

Aims Atrial fibrillation (AF) is the most common cardiac arrhythmia. Pathogenic variants in
genes encoding ion channels are associated with familial AF. The point mutation M1875T in …

State-of-the-art innovations in optical cardiac electrophysiology are significantly enhancing
cardiac research. A potential leap into patient care is now on the horizon. Optical map** …

Sudden cardiac death in children and young adults is a relatively rare but tragic event
whose pathophysiology is unknown at the molecular level. Evidence indicates that the main …