Stimuli-responsive polymer-based nanosystems for cancer theranostics

D Wei, Y Sun, H Zhu, Q Fu - ACS nano, 2023 - ACS Publications
Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen
species (ROS), glutathione (GSH), and pH, biological stimuli, such as enzymes, and external …

TET (Ten-eleven translocation) family proteins: structure, biological functions and applications

X Zhang, Y Zhang, C Wang, X Wang - Signal transduction and targeted …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Map** epigenetic modifications by sequencing technologies

X Chen, H Xu, X Shu, CX Song - Cell Death & Differentiation, 2025 - nature.com
The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …

TET enzymes in the immune system: from DNA demethylation to immunotherapy, inflammation, and cancer

IF López-Moyado, M Ko, PG Hogan… - Annual review of …, 2024 - annualreviews.org
Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …

Simultaneous sequencing of genetic and epigenetic bases in DNA

J Füllgrabe, WS Gosal, P Creed, S Liu, CK Lumby… - Nature …, 2023 - nature.com
DNA comprises molecular information stored in genetic and epigenetic bases, both of which
are vital to our understanding of biology. Most DNA sequencing approaches address either …

Direct enzymatic sequencing of 5-methylcytosine at single-base resolution

T Wang, JM Fowler, L Liu, CE Loo, M Luo… - Nature chemical …, 2023 - nature.com
methylcytosine (5mC) is the most important DNA modification in mammalian genomes. The
ideal method for 5mC localization would be both nondestructive of DNA and direct, without …

DMRT1 regulates human germline commitment

N Irie, SM Lee, V Lorenzi, H Xu, J Chen, M Inoue… - Nature Cell …, 2023 - nature.com
Germline commitment following primordial germ cell (PGC) specification during early human
development establishes an epigenetic programme and competence for gametogenesis …

Whole-genome map** of epigenetic modification of 5-formylcytosine at single-base resolution by chemical labeling enrichment and deamination sequencing

JH Ding, G Li, J **ong, FL Liu, NB **e, TT Ji… - Analytical …, 2024 - ACS Publications
DNA cytosine methylation (5-methylcytosine, 5mC) is a predominant epigenetic modification
that plays a critical role in a variety of biological and pathological processes in mammals. In …

Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells

A Onodera, E González-Avalos, CWJ Lio, RO Georges… - Genome Biology, 2021 - Springer
Background TET enzymes mediate DNA demethylation by oxidizing 5-methylcytosine (5mC)
in DNA to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine …

Simultaneous single-cell analysis of 5mC and 5hmC with SIMPLE-seq

D Bai, X Zhang, H **ang, Z Guo, C Zhu, C Yi - Nature Biotechnology, 2025 - nature.com
Abstract Dynamic 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)
modifications to DNA regulate gene expression in a cell-type-specific manner and are …